Strategies to Reduce Transmission of Antimicrobial Resis

减少抗菌素耐药性传播的策略

基本信息

  • 批准号:
    7332558
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

This study will determine if rates of colonization and infection with 2 resistant Gram positive bacteria?methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE)?among patients in adult intensive care units (ICUs) are lower in ICUs that use an intensive infection control strategy plus standard care compared to ICUs that use standard care alone. The intensive control strategy involves: 1) identifying patients who are colonized with MRSA or VRE by reporting the results of surveillance cultures of the anterior nares and stool or perianal area; 2) Universal Gloving (use of gloves during interactions with the patient or the patient?s environment) until the patients are discharged or their surveillance culture results show they are not colonized with MRSA or VRE (whichever happens first); and 3) Contact Precautions (use of gloves and gowns during interactions with the patient or the patient?s environment) during care of patients who are colonized with MRSA or VRE. Standard care involves proper hand hygiene (handwashing or use of a waterless hand antiseptic) and use of Standard Precautions (use of gloves and other barriers as needed for interactions involving contact with mucous membranes, wounds, and body fluids) and collection of surveillance cultures, but not reporting of results to these sites. The surveillance cultures will be performed by obtaining swabs of the nose and stool or perianal area from patients upon admission to the ICU, at weekly intervals thereafter, and upon discharge from the ICU. The results of the surveillance cultures will be used to compare the rate of colonization with MRSA and VRE in ICUs using the intensive control strategy with those that use standard care alone. Progress Report: This study is a multi-center trial supported by the National Institute of Allergy and Infectious Diseases (NIAID) and is conducted through the Bacteriology and Mycology Study Group, a clinical trials network funded by NIAID. Male and female patients, ages 18 and above, who are admitted to the MICU, SICU or MICU/SICU at one of the 20 participating sites are eligible for the study. The NIH Clinical Center provides the microbiology support for this protocol and has no direct patient contact. All microbiology specimens from participating sites are sent to the Department of Laboratory Medicine. The specimens are processed and recorded in the BAMBU database. In addition to providing microbiology support for the participating sites, several sub-studies are underway testing novel rapid diagnostic tools for MRSA and VRE against culture results. We have enrolled 20,059 patients and the study is now closed for enrollment. (Last day for enrollment was August 25, 2006). Data analysis is underway and should be complete by years end.
本研究将确定2种耐药革兰氏阳性菌的定植率和感染率?耐甲氧西林金黄色葡萄球菌(MRSA)和耐万古霉素肠球菌(VRE)?在成人重症监护病房(ICU)中,使用强化感染控制策略加标准护理的ICU患者的感染率低于仅使用标准护理的ICU患者。强化控制策略包括:1)通过报告前鼻孔和粪便或肛周区域的监测培养结果来识别MRSA或VRE定植的患者; 2)通用手套(在与患者或患者互动期间使用手套?的环境),直到病人出院或他们的监测培养结果显示他们没有定植MRSA或VRE(以先发生者为准);和3)接触预防措施(在与病人或病人的互动过程中使用手套和长袍?的环境),在护理的病人谁是定植与MRSA或VRE。标准护理包括适当的手部卫生(洗手或使用无水手部消毒剂)和使用标准预防措施(根据与粘膜、伤口和体液接触的相互作用需要使用手套和其他屏障),以及收集监测培养物,但不向这些研究中心报告结果。将通过在患者入住ICU时、此后每周一次以及从ICU出院时采集患者的鼻和粪便或肛周区域拭子进行监测培养。监测培养的结果将用于比较ICU中使用强化控制策略与仅使用标准治疗策略的MRSA和VRE定植率。 进度报告:这项研究是由国家过敏和传染病研究所(NIAID)支持的多中心试验,并通过细菌学和真菌学研究组进行,这是一个由NIAID资助的临床试验网络。在20家参与研究中心之一入住MICU、SICU或MICU/SICU的18岁及以上男性和女性患者有资格参加本研究。NIH临床中心为本方案提供微生物学支持,不直接接触患者。将参与研究中心的所有微生物学标本送至实验室医学部。标本经过处理并记录在BAMBU数据库中。除了为参与研究中心提供微生物学支持外,还正在进行几项子研究,根据培养结果测试MRSA和VRE的新型快速诊断工具。我们已入组20,059例患者,研究现已关闭入组。(Last登记日为2006年8月25日)。数据分析正在进行中,应在年底前完成。

项目成果

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Naomi P O'Grady其他文献

Naomi P O'Grady的其他文献

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{{ truncateString('Naomi P O'Grady', 18)}}的其他基金

Antibiotic Therapy for Pts with Pulmonary Infiltrates
肺部浸润患者的抗生素治疗
  • 批准号:
    6825428
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Empiric Antibiotic Therapy for Patients with Pulmonary I
I 型肺病患者的经验性抗生素治疗
  • 批准号:
    7332161
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Empiric Antibiotic Therapy for Patients with Pulmonary I
I 型肺病患者的经验性抗生素治疗
  • 批准号:
    7215798
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Strategies to Reduce Transmission of Antimicrobial Resis
减少抗菌素耐药性传播的策略
  • 批准号:
    7215818
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Empiric Antibiotic Therapy for Pulmonary Infiltrates
肺部浸润的经验性抗生素治疗
  • 批准号:
    7003971
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
Strategies to Reduce Transmission of Antimicrobial Resistant Bacteria in ICUs
减少 ICU 内耐药细菌传播的策略
  • 批准号:
    8565322
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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  • 批准号:
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RAPID:协作研究:通过元群体建模制定减少公共场所 COVID-19 传播的策略
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RAPID: Collaborative Research: Metapopulation Modeling to Develop Strategies to Reduce COVID-19 Transmission in Public Spaces
RAPID:协作研究:通过元群体建模制定减少公共场所 COVID-19 传播的策略
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RAPID: Collaborative Research: Metapopulation Modeling to Develop Strategies to Reduce COVID-19 Transmission in Public Spaces
RAPID:协作研究:通过元群体建模制定减少公共场所 COVID-19 传播的策略
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Strategies to reduce vertical transmission of multi-drug resistant pathogens to neonates (NeoVT-AMR)
减少多重耐药病原体向新生儿垂直传播的策略 (NeoVT-AMR)
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Understanding spatial and population mixing variations in the transmission dynamics of respiratory syncytial virus (RSV) to inform RSV vaccine delivery strategies which optimize population-level vaccine and reduce disparities: development and validation o
了解呼吸道合胞病毒 (RSV) 传播动态的空间和人群混合变化,为 RSV 疫苗接种策略提供信息,从而优化人群水平疫苗并减少差异:开发和验证
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Strategies to Reduce Transmission of Antimicrobial Resis
减少抗菌素耐药性传播的策略
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  • 财政年份:
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Strategies to Reduce Transmission of Antimicrobial Resis
减少抗菌素耐药性传播的策略
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    7215847
  • 财政年份:
  • 资助金额:
    --
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Strategies to Reduce Transmission of Antimicrobial Resis
减少抗菌素耐药性传播的策略
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  • 财政年份:
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减少耐药细菌传播的策略
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  • 财政年份:
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