PANCREAS CANCER PROGRAM

胰腺癌计划由一个专注于胰腺的多学科研究小组组成 内分泌癌或导管癌(PDAC)。这些调查人员包括一个多学科团队， 内分泌学、胃肠病学、内科肿瘤学、放射肿瘤学和 外科肿瘤学，准备解决胰腺癌的关键问题，全面整合 基础科学和人口科学的教员。该计划的科学目标是： 了解影响PDAC和胰腺疾病风险的遗传和环境因素 神经内分泌肿瘤的发生。 了解胰腺癌早期发生的遗传和生物学事件，以期发展 更好的诊断工具。 了解促进胰腺癌进展的因素，特别强调PDAC 间质与侵袭和转移生物学。 了解PDAC和胰腺癌化疗耐药和敏感性的基础 神经内分泌肿瘤。 开发新的范例和模型系统，以评估特定基因在启动和 这些癌症的进展。 使用这样的模型系统评估新的靶向治疗，无论是单独使用还是与 常规细胞毒药物，用于治疗PDAC和胰腺神经内分泌肿瘤。 该计划包括来自医学院8个系的15名成员。该计划有 上一预算年度同行审查支助总额2 444 680美元。该计划有8%的计划内 和34%的方案间出版物。

The Pancreas Cancer Program comprises a multi-disciplinary group of investigators focused on pancreatic cancer of either endocrine or ductal origin (PDAC). These investigators include a multidisciplinary team of clinicians and clinical scientists in endocrinology, gastroenterology, medical oncology, radiation oncology and surgical oncology who are poised to address critical issues in pancreatic cancer, with full integration of faculty in basic and population sciences. The scientific goals of the program are to: Understand the genetic and environmental factors that influence risk for PDAC and pancreatic neuroendocrine tumor development. Understand the genetic and biologic events occurring early in pancreas cancer, with a view to developing better diagnostic tools. Understand the factors that promote progression of pancreas cancer, with a special emphasis on PDAC stroma and the biology of invasion and metastasis. Understand the basis of chemotherapy resistance and sensitivity in PDAC and pancreatic neuroendocrine tumors. Develop new paradigms and model systems to evaluate the role of specific genes in the initiation and progression of these cancers. Use such model systems to evaluate new targeted therapeutics, either alone or in combination with conventional cytotoxic agents, in the treatment of PDAC and pancreatic neuroendocrine tumors. The program includes 15 members from 8 departments in the School of Medicine. The Program has $2,444,680 Total peer reviewed support for the last budget year. The Program has 8% intra-programmatic and 34% inter-programmatic publications.