Bioinformatics training on Schistosomiasis, malaria, leishmaniasis, Chaga's

关于血吸虫病、疟疾、利什曼病、白桦茸病的生物信息学培训

• 批准号: 7249405
• 负责人: Jessica C Kissinger
• 金额: $ 22.33万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249405
• 关键词: Algorithms; Anopheles Genus; Architecture; Area; Bioinformatics; Biomphalaria; Brazil; Complement; Databases; Development; Disease; Drug Delivery Systems; Educational workshop; Evolution; Exercise; Funding; Gene Expression Profile; Genetic; Genome; Geographic Information Systems; Goals; Grant; Heart Diseases; Housing; Human; Institutes; Internet; Knowledge; Laboratories; Leishmania; Leishmaniasis; Malaria; Microarray Analysis; Molecular Epidemiology; Organism; Parasites; Phylogenetic Analysis; Plasmodium falciparum; Polymorphism Analysis; Population Genetics; Postdoctoral Fellow; Proteomics; Qualifying; Research; Research Infrastructure; Research Personnel; Research Project Grants; Rural; Schistosoma; Schistosoma mansoni; Schistosomiasis; Site; Students; System; Technology; Training; Training Programs; Trypanosoma cruzi; USA Georgia; United States National Institutes of Health; Universities; Vaccines; Virginia; Western Asia Georgia; design; desire; disease transmission; genetic epidemiology; genome database; genome sequencing; programs; statistics; training project; vector

This proposal represents a collaborative training partnership between researchers at the University of Georgia, the Virginia Bioinformatics Institute, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro and the Centro de Pesquisas Rene Rachou - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 15 laboratories and 3 funded NIH grants (A training grant in emerging and re-emerging diseases, an ICIDR grant on host genetic correlates in schistosomiasis and a grant on the genetic architecture of heart disease in rural Brazil". The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium falciparum, Trypanosoma cruzi, Leishmania sp., Schistosoma mansoni, Anopheles, Biomphalaria and Humans. This proposal is designed to meet the needs of the CPqRR by initiating a 5-year targeted training program that involves pre-and post-doctoral students from many of the 15 laboratories at the CPqRR. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the creation of a Schistosoma genome relational database housed and served from the CPqRR. Training conducted will include in systems management, web design, networking, algorithms, PERL programming, proteomics, bioinformatics, databases, GIS/GPS, statistics and phylogenetics. Projects supported will relate to genome sequencing, transcriptome analysis, polymorphism detection, genome annotation, microarray analysis, genome database development, identification of drug targets, identification of vaccine targets, genetic epidemiology, georeferencing and GIS for the prediction of disease transmission sites, phylogenomics and population genetics, among others. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a local training center of excellence.

这项建议代表了格鲁吉亚大学、弗吉尼亚生物信息学研究所、里约热内卢Oswaldo Cruz-FIOCRUZ研究所和巴西贝洛奥里藏特Rene Rachou研究中心的研究人员之间的合作培训伙伴关系。CPqRR目前有15个实验室和3个国家卫生研究院资助的赠款（新出现和重新出现疾病的培训赠款，ICIDR关于血吸虫病宿主遗传相关性的赠款和巴西农村心脏病遗传结构的赠款）。本培训提案的目标是在CPqRR建立生物信息学、流行病学和分子进化领域的可持续核心基础设施，以补充现有NIH资助的研究，并促进其他实验室进行的研究。CPqRR的研究重点是热带寄生虫，它们的载体和宿主。这些生物体包括：恶性疟原虫、克氏锥虫、利什曼原虫，曼氏血吸虫、按蚊、双脐吸虫和人类。该提案旨在通过启动一项为期5年的有针对性的培训计划来满足CPqRR的需求，该计划涉及来自CPqRR 15个实验室中许多实验室的博士前和博士后学生。高级培训将通过巴西国内外的讲习班、课程、短期和长期培训进行。培训将涉及源自CPqRR需求的合作研究项目，重点关注血吸虫病的几个方面。这次培训的统一项目将是建立一个血吸虫基因组关系数据库，由CPqRR提供服务。 所进行的培训将包括系统管理、网页设计、联网、算法、PERL编程、蛋白质组学、生物信息学、数据库、地理信息系统/全球定位系统、统计和遗传学。 所支助的项目将涉及基因组测序、转录组分析、多态性检测、基因组注释、微阵列分析、基因组数据库开发、确定药物目标、确定疫苗目标、遗传流行病学、预测疾病传播地点的地理参照和地理信息系统、基因组学和人口遗传学等。 从这次培训和实施活动中获得的技术和知识将直接适用于其他寄生生物的研究。我们将积极寻找合格的培训候选人，他们有强烈的愿望返回，并将他们新获得的专业知识贡献给当地的卓越培训中心。