Infectious Disease Genomics and Bioinformatics Training in Brazil

描述(由申请者提供)：本提案代表格鲁吉亚大学、里约热内卢奥斯瓦尔多·克鲁斯-菲奥克鲁斯研究所、米纳斯吉拉斯联邦大学和巴西贝洛奥里藏特佩斯基萨雷内·拉乔中心(CPQRR)-菲奥克鲁斯的研究人员之间现有的ITGH D43合作培训伙伴关系的续展。CPqRR目前拥有14个实验室和5个由NIH资助的研究奖项。这项培训提案的目标是在CPqRR在生物信息学、流行病学和分子进化领域建立一个可持续的核心基础设施，以补充国家卫生研究院资助的现有研究，并促进在其他实验室进行的研究。CPqRR的研究重点是热带寄生虫、它们的媒介和它们的宿主。这些生物包括：疟原虫、克鲁氏锥虫。弓形虫、曼氏血吸虫。按蚊、白纹伊蚊和人类。这项建议旨在满足CPqRR的需求，继续实施一项卓有成效的培训计划，该计划包括CPqRR 14个实验室中许多实验室的博士后和博士后学生，再持续5年。高级培训将通过讲习班、课程、短期和长期培训在巴西国内和国外进行。培训将涉及合作研究项目，这些项目源于CPqRR的需要，侧重于血吸虫病的几个方面。这一培训的统一项目将是继续维护和扩展(包括种群多样性和其他“组学”数据)血吸虫基因组数据库，该数据库是在培训奖的第一阶段创建并保存CPqRR的。分子进化培训将侧重于血吸虫媒介、血吸虫和流行病学/生物统计数据，并将从现有资助项目中得出和分析这些数据。从这次培训和实施演习中获得的技术和知识将直接适用于对其他寄生生物的研究。我们将积极寻找有强烈意愿回国参加培训的合格候选人，并为新成立的生物信息学中心的继续发展贡献他们新获得的专业知识。 公共卫生相关性：迫切需要针对寄生虫病的新药和疫苗靶标。技术的进步为我们提供了新的数据，涵盖了寄生虫生物学的许多方面。但是，新的数据很复杂，需要复杂的计算分析和数据库。这项提议旨在培训流行地区的新一代研究人员使用这些新数据来帮助治愈疾病。

DESCRIPTION (provided by applicant): This proposal represents a renewal of a current ITGH D43 collaborative training partnership between researchers at the University of Georgia, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro, the Universidade Federal de Minas Gerais and the Centro de Pesquisas Rene Rachou (CPqRR) - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 14 laboratories and 5 funded NIH research awards. The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH-funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR Is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans. This proposal is designed to meet the needs ofthe CPqRR by continuing a very productive training program that involves pre-and post-doctoral students from many of the 14 laboratories at the CPqRR for an additional 5 years. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the continued maintenance and extension (to include population diversity and other "omics" data) of a Schistosoma genome database created and housed the CPqRR during the first phase of the training award. Molecular evolution training will focus on the Schistosome vector, Blomphalaria and epidemiological/biostatistlcal data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a newly founded Center of Bioinformatics. PUBLIC HEALTH RELEVANCE: The need for new drug and vaccine targets for parasitic diseases is tremendous. Advances in technology have provided us with new data that cover many aspects of the biology of the parasites. But, the new data are complex and require sophisticated computational analyses and databases. This proposal is designed to train a new generation of researchers in endemic areas to use this new data to help cure disease.