CRCNS: An Integrated Locomotion Model for Lamprey Swimming

CRCNS：七鳃鳗游泳的综合运动模型

• 批准号: 7435327
• 负责人: AVIS H COHEN
• 金额: $ 27.59万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7435327
• 关键词: Acute; Animals; Automobile Driving; Behavior; Biological Models; Body Fluids; Cells; Complex; Computer Simulation; Condition; Consultations; Coupling; Data; Decompression Sickness; Elements; Encapsulated; Environment; Excision; Face; Feedback; Healed; Knowledge; Lampreys; Lesion; Life; Liquid substance; Locomotion; London; Maps; Measurement; Measures; Mechanics; Mechanoreceptors; Modeling; Motion; Motor; Movement; Muscle; Nerve; Neuromechanics; Organ; Organism; Output; Pattern; Performance; Peripheral; Phase; Physiological; Preparation; Protocols documentation; Range; Reaction; Research Personnel; Role; Running; Sensory; Simulate; Skin; Spinal; Spinal Cord; Swimming; System; Testing; Travel; Universities; Variant; Water; Work; analog; body mechanics; central pattern generator; data modeling; healing; kinematics; lateral line; lateral line (brain); mathematical model; neuroregulation; pressure; receptor; relating to nervous system; research study; response; sensory feedback; sensory system; spinal tract

DESCRIPTION (provided by applicant): Locomotion is the product of neural output acting on muscles driving a mechanically complex body in an unpredictable environment. The lamprey is a simple, well-studied and relatively tractable vertebrate model with which to probe this neuromechanical system. We hypothesize that steady locomotion in a predictable environment requires only the central pattern generator (CPG) without the necessity of other input. We also hypothesize that in an unpredictable environment sensory feedback combined with strong intersegmental coupling is necessary. To investigate these hypotheses we will develop an integrated model, of lamprey swimming LAMPREYCOMP with Thelma Williams, from London, and researchers Philip Holmes and Alexander Smits from Princeton University. The model spans CPG, sensory feedback, muscle mechanics, body mechanics, and fluid mechanics, and is a full model of a complex behavior in a vertebrate, albeit a simple one. Cohen and colleagues will perform experimental studies of the CPG and its response to sensory feedback from spinal mechanoreceptors, skin and lateral line and will develop the component of LAMPREYCOMP that maps sensory input to motor nerve output. Work on muscle and body mechanics will be done by Holmes and Williams. Smits and Holmes will study the fluid mechanics of the swimming animals both experimentally and theoretically. The experimental work will include developing a mechanical analog, P-RAY, whose motion will be adjusted to reproduce that of live animals, allowing measurements of fluid motion and pressure variations along the body. The theoretical work will include developing the fluid dynamical component of LAMPREYCOMP, in consultation with C. Peskin, L. Fauci and colleagues. LAMPREYCOMP will be tested to insure that it reproduces the behavior of whole animal swimming, various reduced preparations and P-RAY. It will then be used to investigate the effect of manipulations, such as removing sensory feedback from spinal mechanoreceptors that are not experimentally possible. We also show that all components of the protocol are possible. Because the lamprey is a model system for all of vertebrate locomotion, our hypotheses and models will have broad implications for more advanced organisms in which such a complete approach is not presently feasible.

描述（由申请人提供）：运动是神经输出作用于肌肉的产物，在不可预测的环境中驱动机械复杂的身体。七鳃鳗是一个简单的，经过充分研究和相对听话的脊椎动物模型，以探讨这一神经机械系统。我们假设，在一个可预测的环境中，稳定的运动只需要中央模式发生器（CPG）没有其他输入的必要性。我们还假设，在一个不可预测的环境中，感觉反馈结合强烈的节段间耦合是必要的。为了研究这些假设，我们将开发一个综合模型，七鳃鳗游泳LAMPREYCOMP与塞尔玛威廉姆斯，从伦敦，研究人员菲利普霍姆斯和亚历山大斯密茨从普林斯顿大学。该模型跨越了CPG、感觉反馈、肌肉力学、身体力学和流体力学，是脊椎动物复杂行为的完整模型，尽管是一个简单的模型。Cohen及其同事将对CPG及其对来自脊髓机械感受器、皮肤和侧线的感觉反馈的反应进行实验研究，并将开发LAMPREYCOMP的组件，将感觉输入映射到运动神经输出。关于肌肉和身体力学的工作将由霍姆斯和威廉姆斯完成。Smits和Holmes将从实验和理论两方面研究游泳动物的流体力学。实验工作将包括开发一种机械模拟物P-RAY，其运动将被调整以再现活体动物的运动，从而允许测量流体运动和身体沿着的压力变化。理论工作将包括与C.佩斯金湖Fauci和同事们。将对LAMPREYCOMP进行试验，以确保其再现整个动物游泳、各种还原制剂和P射线的行为。然后，它将被用来研究操纵的效果，例如从脊髓机械感受器中去除感觉反馈，这在实验上是不可能的。我们还表明，该协议的所有组件都是可能的。因为七鳃鳗是一个模型系统的所有脊椎动物的运动，我们的假设和模型将有广泛的影响，更先进的生物体中，这样一个完整的方法是目前不可行的。