Spatial, Temporal, Social Disparities in Breast Cancer

乳腺癌的空间、时间和社会差异

• 批准号: 7530553
• 负责人: Mario Schootman
• 金额: $ 42.62万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7530553
• 关键词: Accounting; Address; American Medical Association; Area; Australia; Bayesian Method; Behavioral Risk Factor Surveillance System; Breast Cancer Detection; Cancer Etiology; Censuses; Cessation of life; Characteristics; Condition; Country; County; Data; Detection; Diagnostic Neoplasm Staging; Disease; Europe; European; Geography; Health; Health Planning; In Situ; Incidence; Inequality; Interdisciplinary Study; Intervention; Iowa; Legal; Link; Locally Advanced Malignant Neoplasm; Malignant Neoplasms; Mammography; Measures; Mediating; Medical Surveillance; Modeling; Monitor; NCI Strategic Plan to Reduce Health Disparities; Neoplasm Metastasis; New Zealand; Numbers; Outcome; Pathway interactions; Pattern; Physicians; Population; Population Density; Positive Lymph Node; Prevalence; Primary Care Physician; Public Health; Purpose; Randomized Controlled Clinical Trials; Range; Rate; Recommendation; Relative (related person); Resources; SEER Program; San Francisco; Screening Result; Screening procedure; Services; Staging; Techniques; Testing; Time; United States; United States Food and Drug Administration; Variant; Vermont; Woman; aged; base; cost; deprivation; experience; geographic difference; indexing; lymph nodes; malignant breast neoplasm; mortality; prevent; programs; size; social; social disparities; social inequality; socioeconomics; statistics; tool; trend; tumor

DESCRIPTION (provided by applicant): Screening for breast cancer reduces mortality. Following the implementation of screening programs, European studies have shown that the incidence of early-stage and in situ breast cancers increased substantially. This was followed by a decline in the incidence of advanced-stage breast cancers, which approximated the size of the reduction in mortality rates. This pathway of effects towards mortality reduction resulting from screening would also be expected in the United States, but studies examining such reduction are currently lacking. Monitoring the effects of breast cancer screening in the United States among counties is clearly beneficial since this will facilitate local health planning and allocation of screening resources. Although screening use varies geographically, the extent to which changes over time in the effects of screening have varied among different counties in the United States is unclear. One explanation for the geographic variation in screening is that women from socioeconomically deprived areas are less likely to be screened. Because of the importance of physician recommendation to breast cancer screening and the mediating effect of primary care physician and mammography facility availability in the association between area deprivation and various health outcomes, we hypothesize that the differences in effect of breast cancer screening among counties with varying socioeconomic conditions will be mediated by the availability of primary care physicians and mammography facilities locally. In the second revision of this proposal, we will use an ecological study to: (1) Investigate the spatio-temporal variation of early stage breast cancer, advanced stage breast cancer, and breast cancer mortality at the county-level using 1988-2005 data from nine SEER programs and 200 counties; (2) Determine the association of the county-specific variation of breast cancer screening prevalence with the county-specific incidence of advanced stage breast cancer and with breast cancer mortality; (3) Determine if temporal changes in early stage breast cancer, advanced stage breast cancer, and breast cancer mortality vary by county socioeconomic conditions; and (4) Determine if the availability of primary care physicians and mammography facilities at the county level explains the temporal differences between affluent and socioeconomically deprived counties in the incidence of early stage breast cancer, advanced stage breast cancer, and breast cancer mortality. Bayesian methods will be used as part of spatio-temporal models. PUBLIC HEALTH RELEVANCE: Monitoring the effects of breast cancer screening in the United States among counties is clearly beneficial since this will facilitate local health planning and allocation of screening resources. We will use an ecological study to: (1) Investigate the spatio-temporal variation of early stage breast cancer, advanced stage breast cancer, and breast cancer mortality at the county-level using 1988-2005 data from nine SEER programs and 200 counties; (2) Determine the association of the county-specific variation of breast cancer screening prevalence with the county-specific incidence of advanced stage breast cancer and with breast cancer mortality; (3) Determine if temporal changes in early stage breast cancer, advanced stage breast cancer, and breast cancer mortality vary by county socioeconomic conditions; and (4) Determine if the availability of primary care physicians and mammography facilities at the county level explains the temporal differences between affluent and socioeconomically deprived counties in the incidence of early stage breast cancer, advanced stage breast cancer, and breast cancer mortality.

描述（由申请人提供）：乳腺癌筛查可降低死亡率。在实施筛查方案后，欧洲的研究表明，早期和原位乳腺癌的发病率大幅增加。随后晚期乳腺癌的发病率下降，与死亡率的下降幅度大致相当。在美国，这种通过筛查降低死亡率的作用途径也是可以预期的，但目前缺乏研究来检查这种降低。监测美国各县乳腺癌筛查的效果显然是有益的，因为这将有助于当地的健康规划和筛查资源的分配。虽然筛查的使用在地理上各不相同，但美国不同县之间筛查效果随时间变化的程度尚不清楚。筛查的地理差异的一个解释是，来自社会经济贫困地区的妇女不太可能接受筛查。由于医生建议乳腺癌筛查的重要性和初级保健医生和乳房X光检查设施的可用性在区域剥夺和各种健康结果之间的关联的中介作用，我们假设，不同社会经济条件的县之间的乳腺癌筛查效果的差异将介导的初级保健医生和乳房X光检查设施的可用性当地。在第二次修订中，我们将使用生态学研究：（1）利用1988-2005年9个SEER项目和200个县的数据，调查县级水平的早期乳腺癌、晚期乳腺癌和乳腺癌死亡率的时空变化;（2）确定乳腺癌筛查患病率的县特异性变化与晚期乳腺癌的县特异性发病率和乳腺癌死亡率的关系;（3）确定早期乳腺癌、晚期乳腺癌和乳腺癌死亡率的时间变化是否因县的社会经济条件而异;以及（4）确定县一级初级保健医生和乳房X线摄影设施的可用性是否解释了富裕县和社会经济贫困县之间早期乳腺癌发病率的时间差异，晚期乳腺癌和乳腺癌死亡率。贝叶斯方法将被用作时空模型的一部分。公共卫生关系：监测美国各县乳腺癌筛查的效果显然是有益的，因为这将有助于当地的健康规划和筛查资源的分配。本研究采用生态学研究的方法：（1）利用1988-2005年9个SEER项目和200个县的数据，研究县级水平上早期乳腺癌、晚期乳腺癌和乳腺癌死亡率的时空变化;（2）确定乳腺癌筛查患病率的县特异性变化与县的关联-（3）确定早期乳腺癌、晚期乳腺癌和乳腺癌死亡率的时间变化是否因县的社会经济条件而异;以及（4）确定县一级初级保健医生和乳房X线摄影设施的可用性是否解释了富裕县和社会经济贫困县之间早期乳腺癌发病率的时间差异，晚期乳腺癌和乳腺癌死亡率。