CELLULAR HOMOLOGS IN A NEW SIMIAN GAMMAHERPESVIRUS
CELLULAR HOMOLOGS IN A NEW SIMIAN GAMMAHERPESVIRUS
批准号:
6078300
负责人:
TIMOTHY M ROSE
金额:
$28.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-09-30 至 2000-09-29
关键词:
Gammaherpesvirinae Macaca mulatta Macaca nemestrina biochemical evolution cell proliferation chemotaxis cyclins fibrosis histopathology human herpesvirus 8 immunofluorescence technique immunosuppression interleukin 6 macrophage molecular cloning neoplastic transformation nucleic acid sequence peritoneum neoplasm polymerase chain reaction simian virus tissue /cell culture virus genetics virus related neoplasm /cancer
中文摘要
这些研究人员最近发现了两个密切相关的
腹膜后纤维化病变中存在的相关γ疱疹病毒
免疫抑制的猕猴。 初步数据显示,
发现的病毒(称为RFHV)是人类的猿类对应物,
疱疹病毒8,与卡波西肉瘤相关。 在这
应用程序,研究人员建议调查整个基因组
RFHV的结构,以识别和表征RFHV同系物
HHV-8基因组中发现的细胞丝氨酸样基因,并确定
腹膜后纤维化病变中RFHV的患病率。
英文摘要
DESCRIPTION: These investigators have recently identified two closely
related gammaherpesviruses present in retroperitoneal fibrosis lesions of
immunosuppressed macaques. Preliminary data indicate that these newly
discovered viruses (termed RFHV) are the simian counterparts of human
herpesvirus 8, which is associated with Kaposi s sarcoma. In this
application, the investigators propose to investigate the overall genomic
structure of RFHV, to identify and characterize the RFHV homologs of
cellular cytokine-like genes found in the HHV-8 genome, and to determine the
prevalence of RFHV in retroperitoneal fibrosis lesions.
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