ENDOMETRIOSIS IN RHESUS MACAQUES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的了解恒河猴子宫内膜异位症的患病率和家族聚集性。子宫内膜异位症发生在几种有月经周期的非人类灵长类动物中。从1978年到2002年，我们发现了144只患有子宫内膜异位症的恒河猴。我们建立了一个庞大的多代系谱和9个核心家庭，其中包括1,602名女性。子宫内膜异位症的患病率随年龄增长而增加。与未患子宫内膜异位症的动物相比，患子宫内膜异位症的动物之间的平均亲属关系系数显著更高，这有力地提示了子宫内膜异位症的家族聚集性。我们发现，与母亲同父异母的兄弟姐妹和父亲同父异母的兄弟姐妹相比，全同胞的复发风险更高。患病母亲的分离比与非患病母亲相比无显著差异。这些结果支持恒河猴子宫内膜异位症的家族聚集性，并表明这是研究遗传方式、潜在遗传易感基因定位和环境因素影响的一种有前景的动物模型。对谱系和遗传信息的评估仍在继续，并已制定了从存档组织样本中提取DNA的计划。这项研究使用了WNPRC动物服务和老龄资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate the prevalence and familial aggregation of endometriosis in rhesus macaques. Endometriosis occurs in several non-human primate species that have menstrual cycles. Between 1978 and 2002, we identified 144 rhesus macaques with endometriosis. We established a large multigenerational pedigree and nine nuclear families comprising 1,602 females. Prevalence of endometriosis increased with age. Familial aggregation of endometriosis was strongly suggested by a significantly higher average kinship coefficient among affected animals compared with those unaffected. We saw a higher recurrence risk for full siblings when compared to maternal half siblings and paternal half sibs. The segregation ratio among affected mothers was not significantly higher compared with unaffected mothers. The results support familial aggregation of endometriosis in rhesus macaques and indicate that this is a promising animal model for investigating the mode of inheritance, the location of potential genetic susceptibility loci and the influence of environmental factors. Evaluation of pedigree and genetic information is continuing and plans for extracting DNA from archived tissue samples have been made. This research used WNPRC Animal Services and Aging Resources.