ENDOMETRIOSIS IN RHESUS MACAQUES

恒河猴子宫内膜异位症

• 批准号: 7716422
• 负责人: Stephen B. Kennedy
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716422
• 关键词: Affect; Age; Aging; Animal Model; Animals; Archives; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA; Environmental Risk Factor; Evaluation; Female; Funding; Genetic Predisposition to Disease; Grant; Institution; Location; Macaca mulatta; Menstrual cycle; Mothers; Nuclear Family; Online Systems; Prevalence; Recurrence; Reporting; Research; Research Personnel; Resources; Risk; Services; Siblings; Source; Surveys; Tissue Sample; United States National Institutes of Health; endometriosis; genetic pedigree; genome wide association study; nonhuman primate; segregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To investigate the prevalence and familial aggregation of endometriosis in rhesus macaques. Endometriosis occurs in several non-human primate species that have menstrual cycles. Between 1978 and 2002, we identified 144 rhesus macaques with endometriosis. We established a large multigenerational pedigree and nine nuclear families comprising 1,602 females. Prevalence of endometriosis increased with age. Familial aggregation of endometriosis was strongly suggested by a significantly higher average kinship coefficient among affected animals compared with those unaffected. We saw a higher recurrence risk for full siblings when compared to maternal half siblings and paternal half sibs. The segregation ratio among affected mothers was not significantly higher compared with unaffected mothers. The results support familial aggregation of endometriosis in rhesus macaques and indicate that this is a promising animal model for investigating the mode of inheritance, the location of potential genetic susceptibility loci and the influence of environmental factors. Evaluation of pedigree and genetic information is continuing. In the current report period, we isolated DNA from archived and fresh tissue samples for a genome-wide association study. The project is currently expanding to include additional clinical collaborators through our CTSA and a web-based survey of the prevalence of endometrisosis in the colonies of the other NPRCs. This research used WNPRC Animal Services and Aging Resources.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 探讨恒河猴子宫内膜异位症的患病率及其家族聚集性。 子宫内膜异位症发生在几种有月经周期的非人类灵长类动物中。1978年至2002年，我们确定了144恒河猴子宫内膜异位症。我们建立了一个大型的多代系谱和9个核心家庭，包括1,602名女性。子宫内膜异位症的患病率随着年龄的增长而增加。子宫内膜异位症的家族聚集强烈建议受影响的动物与未受影响的动物相比，显着较高的平均亲属关系系数。我们发现，与母亲半同胞和父亲半同胞相比，全同胞的复发风险更高。与未受影响的母亲相比，受影响的母亲之间的隔离率并没有显着更高。结果支持恒河猴子宫内膜异位症的家族聚集性，并表明这是一个有前途的动物模型，调查的遗传方式，潜在的遗传易感基因位点的位置和环境因素的影响。对血统和遗传信息的评估仍在继续。在本报告期内，我们从存档和新鲜组织样本中分离出DNA，用于全基因组关联研究。 该项目目前正在扩大，通过我们的CTSA和基于网络的调查，在其他NPRCs的殖民地中，包括额外的临床合作者。 这项研究使用WNPRC动物服务和老龄化资源。