Exceptional Longevity and Biobehavioral Aging in Rhesus Macaques

恒河猴的超长寿命和生物行为衰老

• 批准号: 10648945
• 负责人: Erin Loraine Kinnally
• 金额: $ 23.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648945
• 关键词: Acceleration; Adult; Age; Aging; Animals; Assessment tool; Attention; Automobile Driving; Behavior; Benchmarking; Biological Aging; Biological Markers; Blood Chemical Analysis; California; Characteristics; Chronology; Cognition; Cognitive; Data; Deceleration; Decision Making; Elderly; Emotional; Exhibits; Expectancy; Experimental Animal Model; Family; Funding; Future; Geriatrics; Goals; Health; Health Promotion; Human; Impaired cognition; In Situ; Individual; Individual Differences; Infant; Intervention; Length; Life; Life Expectancy; Link; Longevity; Macaca; Macaca mulatta; Maps; Mental Depression; Methods; Modeling; Molecular; Monkeys; Motivation; National Institute on Aging; Outcome; Personal Satisfaction; Persons; Phenotype; Primates; Problem Solving; Quality of life; Recording of previous events; Research; Resources; Sensory; Short-Term Memory; Standardization; Stress and Coping; Surveys; Technology; Time; Withdrawal; Work; aged; biobehavior; biopsychosocial; cognitive reserve; disorder risk; emotion regulation; flexibility; genetic pedigree; healthspan; healthy aging; human model; improved; individual variation; innovation; middle age; neural; new technology; nonhuman primate; novel; positive emotional state; programs; promote resilience; prospective; resilience; social; social attention; stress resilience; tool; trait; translational research program

Exceptional Longevity and Biobehavioral Aging in Rhesus Macaques As human lifespan increases, a critical challenge is to simultaneously improve healthspan, the length of time we spend in good health. Studying the unique characteristics of individuals with exceptional longevity (ExLong) is a strategic method to achieve that objective, but it can be challenging to predict who will live longest. The PI has recently discovered that in a highly translational non-human primate (NHP) model of human health, the rhesus macaque, some families exhibit exceptional longevity, analogous to humans. This discovery represents a unique opportunity to identify drivers of a longer, healthier life, because it will allow us to pre-select individuals predisposed to longevity for study. We will focus on identifying the biobehavioral health factors (cognitive engagement, active stress coping, health promoting decisions) that play a role in healthy aging in ExLong individuals, because they can improve well-being as we age, as well as drive healthier outcomes. To accomplish these goals, we propose to create a new tool to survey biobehavioral aging in ExLong individuals and controls in one of the largest resources of aging NHPs in the U.S. - the California National Primate Research Center NIA funded aging colony. This resource includes 100 geriatric (20 years or older) rhesus monkeys, with ~50 new monkeys “aging-in” annually. We will develop an innovative and high-throughput rapid assessment that uses cutting edge technology to capture individual differences in biobehavioral aging: cognitive decline vs. cognitive flexibility, depression vs. resilience, avolition vs. exploration, and social motivation vs. withdrawal. We will then create a biobehavioral aging map in middle aged and geriatric rhesus monkeys. Using these tools, we will validate the familial ExLong model and interrogate the unique biobehavioral characteristics of ExLong individuals. This innovative aging model is anticipated to generate new targets to increase healthspan and longevity.

恒河猕猴中的出色寿命和生物行为衰老 随着人类寿命的增加，一个关键的挑战是同时改善健康状态，时间长度 我们身体健康。研究具有特殊寿命（Exlong）的个体的独特特征 是实现这一目标的战略方法，但是预测谁将寿命最长可能是挑战。 pi 最近发现，在高度翻译的非人类灵长类动物（NHP）的人类健康模型中 豪斯猕猴，一些家庭暴露了特殊的寿命，类似于人类。该发现代表 一个独特的机会来识别更长，更健康的生活的驱动因素，因为这将使我们能够预先选择 个人易于长寿进行研究。我们将专注于确定生物行为的健康因素 （认知参与，主动压力应对，促进健康决定）在健康衰老中发挥作用 Exlong个人，因为随着年龄的增长，他们可以改善幸福感，并且可以推动更健康的结果。到 实现这些目标，我们建议创建一种新工具来调查Exlong个体的生物行为衰老 并控制美国衰老NHP的最大资源之一 - 加利福尼亚国家灵长类动物 研究中心NIA资助的衰老殖民地。该资源包括100个老年病（20岁以上）恒河猴 猴子，每年有大约50只新猴子“老化”。我们将开发创新的高通量快速 使用尖端技术来捕获生物行为衰老的个体差异的评估： 认知能力下降与认知灵活性，抑郁症与韧性，道理与探索和社会 动机与退出。然后，我们将在中年和老年恒河猴中创建一个生物行为的老化图 猴子。使用这些工具，我们将验证家庭巨型模型并审问独特的 exlong个体的生物行为特征。预计这种创新的衰老模型将产生新的 提高健康状况和寿命的目标。