Exceptional Longevity and Biobehavioral Aging in Rhesus Macaques

恒河猴的超长寿命和生物行为衰老

• 批准号: 10648945
• 负责人: Erin Loraine Kinnally
• 金额: $ 23.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648945
• 关键词: Acceleration; Adult; Age; Aging; Animals; Assessment tool; Attention; Automobile Driving; Behavior; Benchmarking; Biological Aging; Biological Markers; Blood Chemical Analysis; California; Characteristics; Chronology; Cognition; Cognitive; Data; Deceleration; Decision Making; Elderly; Emotional; Exhibits; Expectancy; Experimental Animal Model; Family; Funding; Future; Geriatrics; Goals; Health; Health Promotion; Human; Impaired cognition; In Situ; Individual; Individual Differences; Infant; Intervention; Length; Life; Life Expectancy; Link; Longevity; Macaca; Macaca mulatta; Maps; Mental Depression; Methods; Modeling; Molecular; Monkeys; Motivation; National Institute on Aging; Outcome; Personal Satisfaction; Persons; Phenotype; Primates; Problem Solving; Quality of life; Recording of previous events; Research; Resources; Sensory; Short-Term Memory; Standardization; Stress and Coping; Surveys; Technology; Time; Withdrawal; Work; aged; biobehavior; biopsychosocial; cognitive reserve; disorder risk; emotion regulation; flexibility; genetic pedigree; healthspan; healthy aging; human model; improved; individual variation; innovation; middle age; neural; new technology; nonhuman primate; novel; positive emotional state; programs; promote resilience; prospective; resilience; social; social attention; stress resilience; tool; trait; translational research program

Exceptional Longevity and Biobehavioral Aging in Rhesus Macaques As human lifespan increases, a critical challenge is to simultaneously improve healthspan, the length of time we spend in good health. Studying the unique characteristics of individuals with exceptional longevity (ExLong) is a strategic method to achieve that objective, but it can be challenging to predict who will live longest. The PI has recently discovered that in a highly translational non-human primate (NHP) model of human health, the rhesus macaque, some families exhibit exceptional longevity, analogous to humans. This discovery represents a unique opportunity to identify drivers of a longer, healthier life, because it will allow us to pre-select individuals predisposed to longevity for study. We will focus on identifying the biobehavioral health factors (cognitive engagement, active stress coping, health promoting decisions) that play a role in healthy aging in ExLong individuals, because they can improve well-being as we age, as well as drive healthier outcomes. To accomplish these goals, we propose to create a new tool to survey biobehavioral aging in ExLong individuals and controls in one of the largest resources of aging NHPs in the U.S. - the California National Primate Research Center NIA funded aging colony. This resource includes 100 geriatric (20 years or older) rhesus monkeys, with ~50 new monkeys “aging-in” annually. We will develop an innovative and high-throughput rapid assessment that uses cutting edge technology to capture individual differences in biobehavioral aging: cognitive decline vs. cognitive flexibility, depression vs. resilience, avolition vs. exploration, and social motivation vs. withdrawal. We will then create a biobehavioral aging map in middle aged and geriatric rhesus monkeys. Using these tools, we will validate the familial ExLong model and interrogate the unique biobehavioral characteristics of ExLong individuals. This innovative aging model is anticipated to generate new targets to increase healthspan and longevity.

恒河猴的超常寿命和生物行为衰老 随着人类寿命的延长，一个关键的挑战是同时提高健康寿命，即 我们过得很健康。研究超长寿人士的独特特征(ExLong) 是实现这一目标的战略方法，但预测谁能活得最长可能是一件具有挑战性的事情。《少年派》 最近发现，在人类健康的高度翻译的非人类灵长类动物(NHP)模型中， 猕猴，有些家族表现出超乎寻常的长寿，类似于人类。这一发现代表着 一个独特的机会来识别更长、更健康的司机，因为它将允许我们预先选择 倾向于长寿学习的个体。我们将重点确定生物行为健康因素 (认知投入、积极应对压力、促进健康决策)在健康老龄化中发挥作用 超越个体，因为他们可以随着我们年龄的增长而改善幸福感，以及推动更健康的结果。至 为了实现这些目标，我们建议创建一种新的工具来调查Exlong个体的生物行为老化 并控制着美国最大的老化NHP资源之一-加利福尼亚州国家灵长类 研究中心NIA资助了老龄群体。这一资源包括100只老年(20岁或以上)恒河猴 猴子，每年有大约50只新猴子“变老”。我们将开发一种创新的、高通量的快速 使用尖端技术来捕捉生物行为老化中的个体差异的评估： 认知衰退与认知灵活性，抑郁与韧性，撕裂与探索，以及社交 动力VS退缩。然后，我们将创建中年和老年恒河猴的生物行为衰老图谱 猴子。使用这些工具，我们将验证家族ExLong模型并询问唯一的 埃克龙个体的生物行为特征。这一创新的老龄化模式预计将产生新的 目标是增加健康寿命和寿命。