PHYSIOLOGY AND BEHAVIOR OF MATURATION IN WILD BABOONS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。验证和完善四类狒狒类固醇激素的样品采集、储存、提取和检测技术。我们在一定程度上实现了我们的目标，这在一定程度上得益于WNPRC检测服务机构的协助，这使我们能够继续进行开发项目。社会相互作用和环境越来越被认为是对生殖功能、健康和福祉的潜在重要影响。虽然没有男孩生殖成熟的数据，但社会因素会影响女孩的月经初潮时间。视情况而定，青春期提前可能是有益的，也可能是对个人的社会和身体发展或其终生生存和繁殖的不利影响。这项初步研究将首次对非人类灵长类野生种群中青春期时间和青春期长度的个体间差异背后的生理机制以及对这些机制的一些社会影响进行调查。我们将调查行为和社会因素的子集与成熟测量的关联程度，以及可检测到的生理和行为差异之间的时间关系。我们的目标是确定青少年之间的支配地位和攻击性-顺从互动以及青少年与成年人的社会互动在多大程度上预测男性和女性青春期、成熟和成年军衔的生理模式。我们推测这种关系是通过下丘脑-垂体-性腺(HPG)和HP-肾上腺(HPA)轴来调节的。社会环境将以支配地位和决定地位的特定行为的变异性为特征，如空间位移、攻击性和顺从。我们将测量雌激素、雄激素、孕激素和糖皮质激素的粪便激素浓度，并将这些与男性和女性从青春期到青春期和青春期到成年期的行为相关联。实验确定，常见的、广泛传播的和利用的样品存储方法不会导致代谢物的稳定性。确定了稳定代谢物的现场储存和样品处理方法，目前正在我们实验室应用。通过使用早期技术获得的结果被丢弃。这项研究使用了WNPRC Assay Services。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To validate and refine techniques for sample collection, storage, extraction and assay of four classes of baboon steroid hormones. We achieved our objective partly with the assistance of WNPRC Assay Services, which has enabled us to proceed to the developmental project. Social interactions and environment are increasingly recognized as potentially important influences on reproductive function, health, and well-being. Although data are not available for reproductive maturation in boys, social factors influence time of menarche in girls. Depending on circumstances, early puberty may be either an asset or detriment to the social and physical development of the individual or to its lifetime survival and reproduction. This pilot research will provide a first investigation into the physiological mechanisms underlying inter-individual variability in the timing of puberty and the length of adolescence in a wild population of non-human primates and into some of the social impacts on these mechanisms. We shall investigate the extent to which a sub-set of behavioral and social factors correlate with maturational measures and what the temporal relationship is between detectable physiological and behavioral differences. Our aim is to determine the extent to which dominance status and aggressive- submissive interactions among juveniles and the juveniles' social interactions with adults predict physiological patterns of puberty, maturation, and adult rank attainment in males and females. We hypothesize that this relationship is mediated via the hypothalamic-pituitary-gonadal (HPG) and HP-adrenal (HPA) axes. Social environment will be characterized by dominance rank and by variability in the specific behaviors that determine rank, such as, spatial displacements, aggression, and submission. We will measure fecal hormone concentrations of estrogens, androgens, progestins, and glucocorticoids and correlate these with behaviors exhibited during the transition between juvenescence to adolescence and adolescence to adulthood in males and females. Experiments determined that common, broadly disseminated and utilized methods of sample storage did not result in metabolite stability. Methods for field storage and sample processing that do stabilize metabolites were determined and are now being applied in our laboratory. Results obtained through use of the earlier techniques were discarded. This research used WNPRC Assay Services.