PHYSIOLOGY AND BEHAVIOR OF MATURATION IN WILD BABOONS

野生狒狒成熟的生理和行为

• 批准号: 7349434
• 负责人: JEANNE ALTMANN
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349434
• 关键词: PHYSIOLOGY; BEHAVIOR; MATURATION; WILD; BABOONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To validate and refine techniques for sample collection, storage, extraction and assay of four classes of baboon steroid hormones. We achieved our objective partly with the assistance of WNPRC Assay Services, which has enabled us to proceed to the developmental project. Social interactions and environment are increasingly recognized as potentially important influences on reproductive function, health, and well-being. Although data are not available for reproductive maturation in boys, social factors influence time of menarche in girls. Depending on circumstances, early puberty may be either an asset or detriment to the social and physical development of the individual or to its lifetime survival and reproduction. This pilot research will provide a first investigation into the physiological mechanisms underlying inter-individual variability in the timing of puberty and the length of adolescence in a wild population of non-human primates and into some of the social impacts on these mechanisms. We shall investigate the extent to which a sub-set of behavioral and social factors correlate with maturational measures and what the temporal relationship is between detectable physiological and behavioral differences. Our aim is to determine the extent to which dominance status and aggressive- submissive interactions among juveniles and the juveniles' social interactions with adults predict physiological patterns of puberty, maturation, and adult rank attainment in males and females. We hypothesize that this relationship is mediated via the hypothalamic-pituitary-gonadal (HPG) and HP-adrenal (HPA) axes. Social environment will be characterized by dominance rank and by variability in the specific behaviors that determine rank, such as, spatial displacements, aggression, and submission. We will measure fecal hormone concentrations of estrogens, androgens, progestins, and glucocorticoids and correlate these with behaviors exhibited during the transition between juvenescence to adolescence and adolescence to adulthood in males and females. Experiments determined that common, broadly disseminated and utilized methods of sample storage did not result in metabolite stability. Methods for field storage and sample processing that do stabilize metabolites were determined and are now being applied in our laboratory. Results obtained through use of the earlier techniques were discarded. This research used WNPRC Assay Services.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。验证和改进四类狒狒类固醇激素的样品采集、储存、提取和测定技术。 我们在WNPRC Assay Services的协助下部分实现了我们的目标，这使我们能够继续进行开发项目。社会互动和环境越来越被认为是对生殖功能、健康和福祉的潜在重要影响。虽然没有关于男孩生殖成熟的数据，但社会因素影响女孩的初潮时间。视情况而定，青春期提前对个人的社会和身体发育或其一生的生存和生殖可能是有利的，也可能是有害的。这项试点研究将提供一个初步调查的生理机制，潜在的个体间变异的青春期的时间和青春期的长度在一个野生种群的非人类灵长类动物和到这些机制的一些社会影响。我们将研究行为和社会因素的子集与成熟度测量的相关程度，以及可检测的生理和行为差异之间的时间关系。我们的目的是确定青少年之间的支配地位和攻击-顺从互动以及青少年与成年人的社会互动在多大程度上预测了男性和女性的青春期、成熟和成年等级获得的生理模式。我们假设这种关系是通过下丘脑-垂体-性腺（HPG）和HP-肾上腺（HPA）轴介导的。社会环境的特征是支配地位和决定地位的特定行为的可变性，如空间位移、侵略和服从。我们将测量粪便中雌激素、雄激素、孕激素和糖皮质激素的浓度，并将其与男性和女性从幼年到青春期和从青春期到成年期的过渡期间表现出的行为相关联。 实验确定，常见的、广泛传播和使用的样品储存方法不会导致代谢物稳定性。确定了稳定代谢物的现场储存和样品处理方法，目前正在我们的实验室中应用。通过使用早期技术获得的结果被丢弃。本研究使用WNPRC Assay Services。