GENETIC RESOURCES FOR NON-HUMAN PRIMATES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：克隆、基因治疗和干细胞技术正在作为人类生物学模型的各种物种中迅速发展。恒河猴和狒狒是在生物学、生理学和遗传学上与人类最相似的动物模型，也是最适合各种研究应用的动物模型。无论是简单的基因还是复杂的性状，无论是传染病还是环境，恒河猴在直接关系到人类健康的研究中都扮演着重要的角色。但是，猕猴和其他非人类灵长类(HHP)的遗传应用和资源尚未得到充分开发和利用。大多数灵长类动物收容设施没有利用遗传学来协助群体管理，也没有在疫苗或暴露研究等研究应用中考虑与动物的相关性。遗传背景显然在个体的生物反应中起着重要作用，在所有动物和人类研究中都应该更多地加以控制。中心假设是，个体的遗传背景，特别是作为动物模型的遗传背景，对研究研究设计至关重要。研究人员建议开发和促进NHP的遗传资源，特别是恒河猴的遗传资源，并将遗传信息应用于种群管理和研究设计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Cloning, gene therapy, and stem cell technologies are rapidly developing in a variety of species that are models for human biology. Rhesus macaques and baboons are the animal models that most closely resemble humans, biologically, physiologically, and genetically, and are the most feasible for a variety of research applications. Simple gene or complex trait, infectious or environmental, the rhesus macaque plays an important role in research that is directly related to human health. But, genetic applications and resources for the rhesus macaque and other nonhuman primates (NHPs) have not been developed or used to their fullest capacities. Most primate holding facilities have not used genetics to assist with colony management, nor has animal relatedness been considered in research applications, such as vaccine or exposure studies. The genetic background clearly plays an important role in biological responses of an individual and should be more controlled in all animal and human studies. The central hypothesis is that the genetic background of an individual, particularly as an animal model, is vital to research study design. The investigators propose to develop and facilitate the genetic resources of NHPs, particularly rhesus macaque, and apply genetic information to colony management and study design