GENETIC RESOURCES FOR NON-HUMAN PRIMATES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：克隆、基因治疗和干细胞技术在作为人类生物学模型的各种物种中迅速发展。恒河猴和狒狒是在生物学、生理学和遗传学上最接近人类的动物模型，并且对于各种研究应用是最可行的。简单的基因或复杂的性状，传染性或环境，恒河猴在直接关系到人类健康的研究中发挥着重要作用。但是，恒河猴和其他非人灵长类动物（NHP）的遗传应用和资源尚未开发或充分利用。大多数灵长类动物饲养设施没有使用遗传学来协助群体管理，也没有在研究应用中考虑动物的相关性，如疫苗或暴露研究。遗传背景显然在个体的生物学反应中起着重要作用，在所有动物和人类研究中应更加受控。核心假设是个体的遗传背景，特别是作为动物模型，对研究设计至关重要。研究人员建议开发和促进NHP的遗传资源，特别是恒河猴，并将遗传信息应用于群体管理和研究设计

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Cloning, gene therapy, and stem cell technologies are rapidly developing in a variety of species that are models for human biology. Rhesus macaques and baboons are the animal models that most closely resemble humans, biologically, physiologically, and genetically, and are the most feasible for a variety of research applications. Simple gene or complex trait, infectious or environmental, the rhesus macaque plays an important role in research that is directly related to human health. But, genetic applications and resources for the rhesus macaque and other nonhuman primates (NHPs) have not been developed or used to their fullest capacities. Most primate holding facilities have not used genetics to assist with colony management, nor has animal relatedness been considered in research applications, such as vaccine or exposure studies. The genetic background clearly plays an important role in biological responses of an individual and should be more controlled in all animal and human studies. The central hypothesis is that the genetic background of an individual, particularly as an animal model, is vital to research study design. The investigators propose to develop and facilitate the genetic resources of NHPs, particularly rhesus macaque, and apply genetic information to colony management and study design