GENETIC RESOURCES FOR NON-HUMAN PRIMATES

描述(由申请人提供)： 克隆、基因治疗和干细胞技术正在作为人类生物学模型的各种物种中迅速发展。恒河猴和狒狒是在生物学、生理学和遗传学上与人类最相似的动物模型，也是最适合各种研究应用的动物模型。无论是简单的基因还是复杂的性状，无论是传染病还是环境，恒河猴在直接关系到人类健康的研究中都扮演着重要的角色。但是，猕猴和其他非人类灵长类(HHP)的遗传应用和资源尚未得到充分开发和利用。大多数灵长类动物收容设施没有利用遗传学来协助群体管理，也没有在疫苗或暴露研究等研究应用中考虑与动物的相关性。遗传背景显然在个体的生物反应中起着重要作用，在所有动物和人类研究中都应该更多地加以控制。中心假设是，个体的遗传背景，特别是作为动物模型的遗传背景，对研究研究设计至关重要。 研究人员建议开发和促进NHP的遗传资源，特别是恒河猴的遗传资源，并将遗传信息应用于群体管理和研究设计。其目标是在中国建立一个“灵长类遗传学核心”，它将促进现有遗传资源的利用，开发新的NHP遗传资源，并协助需要并可以受益于其研究设计的遗传成分的研究活动。长期目标是提供NHP遗传资源，以便在人类和NHP之间进行更可控和直接的比较，用于遗传和获得性疾病的转移、环境暴露以及用于人类健康应用的基因和药物治疗信息。中国人民共和国非常适合这些遗传活动。兽医学院和校园正在通过聘请遗传学家和建设新的基因组研究设施来专注于基因组学。兽医遗传学实验室已经完成了CNPRC所有恒河猴的基因指纹识别，目前这是作为一项遗传学服务提供给社区的。CNPRC已明确要求并支持Lyons博士在CNPRC建立一个基本的核心设施，并由兽医学院的Lyons博士实验室补充，该实验室具有全面的基因分型和测序能力。这种方法的基本原理是，许多灵长类研究人员不知道目前的灵长类资源，也不熟悉遗传学的使用和优势，因为它超出了他们的专业领域。

DESCRIPTION (provided by applicant): Cloning, gene therapy, and stem cell technologies are rapidly developing in a variety of species that are models for human biology. Rhesus macaques and baboons are the animal models that most closely resemble humans, biologically, physiologically, and genetically, and are the most feasible for a variety of research applications. Simple gene or complex trait, infectious or environmental, the rhesus macaque plays an important role in research that is directly related to human health. But, genetic applications and resources for the rhesus macaque and other nonhuman primates (NHPs) have not been developed or used to their fullest capacities. Most primate holding facilities have not used genetics to assist with colony management, nor has animal relatedness been considered in research applications, such as vaccine or exposure studies. The genetic background clearly plays an important role in biological responses of an individual and should be more controlled in all animal and human studies. The central hypothesis is that the genetic background of an individual, particularly as an animal model, is vital to research study design. The investigators propose to develop and facilitate the genetic resources of NHPs, particularly rhesus macaque, and apply genetic information to colony management and study design. The objective is to establish a "Primate Genetics Core," at the CNPRC, that will facilitate the use of present genetic resources, develop new NHP genetic resources, and assist research activities that require and can benefit from a genetic component to their study design. The long-range goal is to provide NHP genetic resources so that more controlled and direct comparisons can be made between human and NHP, for the transfer of inherited and acquired disease, environmental exposures, and gene and drug therapy information for use in human health applications. The CNPRC is well suited for these genetic activities. The Veterinary School and the campus are focusing on genomics through hiring geneticists and the construction of new genomics research facilities. The Veterinary Genetics Laboratory has accomplished the genetic fingerprinting of all the rhesus macaques at the CNPRC and this is currently provided as a genetics service to the community. The CNPRC has specifically requested and has supported Dr. Lyons with the establishment of a basic core facility at the CNPRC, which is complemented by Dr. Lyons laboratory in the Veterinary School, which has full genotyping and sequencing capabilities. The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise.