GENETIC RESOURCES FOR NON-HUMAN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 克隆、基因治疗和干细胞技术正在作为人类生物学模型的各种物种中迅速发展。恒河猴和狒狒是在生物学、生理学和遗传学上与人类最相似的动物模型，也是最适合各种研究应用的动物模型。无论是简单的基因还是复杂的性状，无论是传染病还是环境，恒河猴在直接关系到人类健康的研究中都扮演着重要的角色。但是，猕猴和其他非人类灵长类(HHP)的遗传应用和资源尚未得到充分开发和利用。大多数灵长类动物收容设施现在都在利用遗传学来协助群体管理。在疫苗或暴露研究等研究应用中，需要考虑动物的相关性。遗传背景显然在个体的生物反应中起着重要作用，在所有动物和人类研究中都应该更多地加以控制。中心假设是，个体的遗传背景，特别是作为动物模型的遗传背景，对研究研究设计至关重要。研究人员建议开发和促进NHP的遗传资源，特别是恒河猴的遗传资源，并将遗传信息应用于群体管理和研究设计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cloning, gene therapy, and stem cell technologies are rapidly developing in a variety of species that are models for human biology. Rhesus macaques and baboons are the animal models that most closely resemble humans, biologically, physiologically, and genetically, and are the most feasible for a variety of research applications. Simple gene or complex trait, infectious or environmental, the rhesus macaque plays an important role in research that is directly related to human health. But, genetic applications and resources for the rhesus macaque and other nonhuman primates (NHPs) have not been developed or used to their fullest capacities. Most primate holding facilities are just now using genetics to assist with colony management. Animal relatedness needs to be considered in research applications, such as vaccine or exposure studies. The genetic background clearly plays an important role in biological responses of an individual and should be more controlled in all animal and human studies. The central hypothesis is that the genetic background of an individual, particularly as an animal model, is vital to research study design. The investigators propose to develop and facilitate the genetic resources of NHPs, particularly rhesus macaque, and apply genetic information to colony management and study design.