VACCINE-ELICITED ANTIBODY DEPENDENT CELL CYTOTOXICITY IN PROTECTION AGAINST SIV

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：为了预防HIV母乳性传播，HIV疫苗应在口腔内病毒暴露的初始部位以及婴儿全身激发抗HIV免疫。这项研究验证了一种假设，即被动转移的SIV特异性抗体可以介导对SIV感染细胞的杀伤(抗体依赖细胞毒性，ADCC)，这种抗体可以保护新生恒河猴免受SIV的口服攻击。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To prevent HIV breast milk transmission, an HIV vaccine should elicit anti-HIV immunity at the initial site of virus exposure in the oral cavity as well as throughout the infants' body. This study tested the hypothesis that passively-transferred, SIV-specific antibodies elicited by vaccination and that can mediate killing of SIV-infected cells (Antibody Dependent Cellular Cytotoxicity, ADCC) may protect against oral SIV challenge of neonatal rhesus macaques.