VACCINE-ELICITED ANTIBODY DEPENDENT CELL CYTOTOXICITY IN PROTECTION AGAINST SIV

疫苗引发的抗体依赖性细胞毒性可预防 SIV

• 批准号: 7349708
• 负责人: Marta L Marthas
• 金额: $ 11.75万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349708
• 关键词: VACCINE; ELICITED; ANTIBODY; DEPENDENT; CELL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To prevent HIV breast milk transmission, an HIV vaccine should elicit anti-HIV immunity at the initial site of virus exposure in the oral cavity as well as throughout the infants' body. This study tested the hypothesis that passively-transferred, SIV-specific antibodies elicited by vaccination and that can mediate killing of SIV-infected cells (Antibody Dependent Cellular Cytotoxicity, ADCC) may protect against oral SIV challenge of neonatal rhesus macaques.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：为了防止HIV母乳传播，HIV疫苗应在口腔和整个婴儿体内的病毒最初暴露部位引起抗HIV免疫。这项研究检验了以下假设：疫苗接种引起的被动转移，SIV特异性抗体，可以介导SIV感染细胞的杀伤（依赖于抗体依赖性细胞毒性，ADCC）可能会预防新生儿鼠尾草新生儿鼠尾草的口服SIV挑战。