VACCINE-ELICITED ANTIBODY DEPENDENT CELL CYTOTOXICITY IN PROTECTION AGAINST SIV

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：为了预防HIV母乳传播，HIV疫苗应该在病毒最初暴露的口腔和整个婴儿体内引发抗HIV免疫。本研究验证了一种假设，即通过疫苗接种诱导的被动转移的SIV特异性抗体（抗体依赖细胞毒性，Antibody Dependent Cellular Cytotoxicity， ADCC）可以介导SIV感染细胞的杀伤，从而保护新生恒河猴免受SIV口服攻击。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To prevent HIV breast milk transmission, an HIV vaccine should elicit anti-HIV immunity at the initial site of virus exposure in the oral cavity as well as throughout the infants' body. This study tested the hypothesis that passively-transferred, SIV-specific antibodies elicited by vaccination and that can mediate killing of SIV-infected cells (Antibody Dependent Cellular Cytotoxicity, ADCC) may protect against oral SIV challenge of neonatal rhesus macaques.