课题基金 / 基金详情

REPLICATING VIRAL VECTOR AS NEONATAL VACCINE TO PREVENT ORAL SIV TRANSMISSION

REPLICATING VIRAL VECTOR AS NEONATAL VACCINE TO PREVENT ORAL SIV TRANSMISSION
复制病毒载体作为新生儿疫苗以预防 SIV 口腔传播
批准号：
7562195
负责人：
Marta L Marthas
金额：
$18.16万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-05-01 至 2008-04-30
来源：
https://reporter.nih.gov/project-details/7562195
关键词：
AttenuatedComputer Retrieval of Information on Scientific Projects DatabaseExposure toFundingGastrointestinal tract structureGrantHIVHIV vaccineImmunityInfantInstitutionNeonatalOralOral cavityProteinsResearchResearch PersonnelResourcesSiteSourceUnited States National Institutes of HealthVaccinesViral VectorViruspreventtransmission process

项目摘要

项目成果

Marta L Marthas的其他基金

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中文摘要
翻译
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：为了防止母乳中反复接触艾滋病毒，新生儿艾滋病毒疫苗应在病毒接触的最初部位（口腔）以及整个婴儿体内激发抗艾滋病毒免疫力。稳定表达HIV蛋白并在口腔和胃肠道中复制的减毒病毒可能是有效的HIV疫苗。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To provide protection against repeated exposure to HIV in breastmilk, a neonatal HIV vaccine should elicit anti-HIV immunity at the initial site of virus exposure the oral cavity as well as throughout the infant's body. Attenuated viruses that stably express HIV proteins and replicate in the oral cavity and the gastrointestinal tract could be efficient HIV vaccines.
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REPLICATING VIRAL VECTOR AS NEONATAL VACCINE TO PREVENT ORAL SIV TRANSMISSION