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Moulting and hatching in nematodes; the role of astacin metalloproteases as potential anti-nematode targets

线虫的蜕皮和孵化；

基本信息

批准号：
BB/D000661/1
负责人：
Antony Page
金额：
$ 28.93万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FD000661%2F1
关键词：
Moulting hatching nematodes role astacin

项目摘要

Parasitic nematodes are a major pest of plants and animals. Around 1 billion people, predominantly in the developing world, harbour parasitic nematodes that cause chronic and debilitating diseases. In addition, nematodes cause a significant economic burden to agriculture, affecting crops and livestock throughout the world. Methods to control nematodes are relatively limited, and drug resistance is becoming common. All nematodes share a common lifecycle growing from an egg through 4 immature larval stages before reaching the sexually mature adult stage. Progression from egg to larvae involves a hatching process, and from individual larval stages to adulthood involves a repeated process termed moulting, where the external skeleton is shed and a new one synthesised. The moulting process allows growth. The astacin enzymes are catalysts that are involved in the processes of hatching, skeleton synthesis and moulting. The specific roles played by this class of enzymes have been confirmed in a model experimental system and will now be examined and characterized in an important veterinary parasite. The nematode Haemonchus contortus is a common and economically significant parasite of sheep and goats. Information gained in this system will also be of relevance in other parasites of animals and plants. The project aims are to identify, study and exploit these enzymes with the overall goal of identifying vaccine and drug targets to treat and control nematode infections.

寄生线虫是动植物的主要害虫。约有10亿人，主要是发展中国家的人，体内寄生线虫，导致慢性和衰弱性疾病。此外，线虫对农业造成重大的经济负担，影响全世界的作物和牲畜。控制线虫的方法相对有限，抗药性正在变得普遍。所有线虫都有一个共同的生命周期，从卵开始，经过4个不成熟的幼虫阶段，然后达到性成熟的成虫阶段。从卵到幼虫的发展涉及孵化过程，从个体幼虫阶段到成年期涉及称为蜕皮的重复过程，其中外部骨骼脱落并合成新的骨骼。蜕皮过程允许生长。虾红素酶是参与孵化、骨架合成和蜕皮过程的催化剂。这类酶所起的特定作用已在模型实验系统中得到证实，现在将在一种重要的兽医寄生虫中进行检查和表征。捻转血矛线虫（Haemonchuscontortus）是绵羊和山羊的一种常见且具有经济意义的寄生虫。在该系统中获得的信息也将与动物和植物的其他寄生虫有关。该项目的目的是鉴定、研究和利用这些酶，其总体目标是确定治疗和控制线虫感染的疫苗和药物靶点。