Haplotype variation at the dopamine transporter gene (SLC6A3): effects on function, endo-phenotypes, cognition and ADHD

多巴胺转运蛋白基因 (SLC6A3) 的单倍型变异：对功能、内表型、认知和 ADHD 的影响

• 批准号: nhmrc : 1043256
• 负责人: A/Pr Mauricio Arcos-Burgos
• 金额: $ 39.07万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/haplotype-variation-dopamine-cognition-adhd/111562
• 关键词: Haplotype; variation; dopamine; transporter; gene

We will investigate variation in the dopamine transporter gene. Variation in this gene will be characterised to a deeper level than has been previously possible using the latest sequencing technology, its biological function will be investigated using biochemical and neuroimaging methods directly in human subjects, and its effects on a clinically important cognitive measure and a common psychiatric condition (attention deficit/hyperactive disorder) will we determined.

我们将调查多巴胺转运蛋白基因的变异。利用最新的测序技术，这种基因的变异将被表征到比以前可能的更深的水平，它的生物学功能将直接在人类受试者中使用生化和神经成像方法进行研究，它对临床上重要的认知指标和常见的精神疾病(注意力缺陷/多动障碍)的影响将被确定。