The role of Steroidogenic Factor 1 in testicular Leydig cells
类固醇生成因子 1 在睾丸 Leydig 细胞中的作用
基本信息
- 批准号:BB/D005043/1
- 负责人:
- 金额:$ 32.43万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2006
- 资助国家:英国
- 起止时间:2006 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Male sexual development and function in mammals is dependent on the products of the testis. The Leydig cells of the testis produce androgens that determine the development of most male secondary characteristics and support sperm production in the adult. Little is known about the factors that regulate Leydig cell differentiation and function. The nuclear hormone receptor SF1 has been implicated in the development of reproductive tissues including the gonad in both mouse and man. Here we aim to study the role of SF1 in Leydig cell differentiation and hormone production in the embryo and adult mouse. As this factor has various roles in the different cell types of the testis, we have devised a strategy to inactivate SF1 specifically within Leydig cells and to identify its tissue specific partner in these cells. These studies will allow us to understand how the cell types of the gonad differentiate and form an organ and how hormone production is regulated in the embryo and adult. In addition, we will uncover molecular pathways that might be implicated in deficiencies of sexual development and reproductive function in humans.
哺乳动物雄性的性发育和功能依赖于睾丸的产物。睾丸的间质细胞产生雄激素,雄激素决定大多数男性次要特征的发育,并支持成年男性的精子生产。对调节间质细胞分化和功能的因素所知甚少。核激素受体SF1在小鼠和人的生殖组织包括性腺的发育中都有作用。本研究旨在研究SF1在胚胎和成年小鼠间质细胞分化和激素产生中的作用。由于该因子在睾丸的不同细胞类型中发挥着不同的作用,我们设计了一种策略,可以在睾丸间质细胞中特异性地灭活SF1,并在这些细胞中识别其组织特异性伴侣。这些研究将使我们了解性腺的细胞类型如何分化并形成一个器官,以及在胚胎和成人中如何调节激素的产生。此外,我们将发现可能与人类性发育和生殖功能缺陷有关的分子途径。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amanda Swain其他文献
IL-15 priming alters IFN-γ regulation in murine NK cells
IL-15 引发改变小鼠 NK 细胞中 IFN-γ 的调节
- DOI:
10.1101/2023.04.23.537947 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Maria;Molly P. Keppel;Anastasiia Gainullina;Changxu Fan;N. Schedler;Amanda Swain;Ana Kolicheski;Hannah Shapiro;Howard A. Young;Ting Wang;M. Artyomov;M. Cooper - 通讯作者:
M. Cooper
Single-cell atlas of healthy human blood unveils age-related loss of NKG2Csup+/supGZMBsup−/supCD8sup+/sup memory T cells and accumulation of type 2 memory T cells
健康人血液单细胞图谱揭示了与年龄相关的 NKG2C⁺GZMB⁻CD8⁺记忆 T 细胞的丧失和 2 型记忆 T 细胞的积累
- DOI:
10.1016/j.immuni.2023.10.013 - 发表时间:
2023-12-12 - 期刊:
- 影响因子:26.300
- 作者:
Marina Terekhova;Amanda Swain;Pavla Bohacova;Ekaterina Aladyeva;Laura Arthur;Anwesha Laha;Denis A. Mogilenko;Samantha Burdess;Vladimir Sukhov;Denis Kleverov;Barbora Echalar;Petr Tsurinov;Roman Chernyatchik;Kamila Husarcikova;Maxim N. Artyomov - 通讯作者:
Maxim N. Artyomov
09-P002 The transcription co-factor Cited2 functions during sex determination and early gonad development
- DOI:
10.1016/j.mod.2009.06.332 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Bill Buaas;Pierre Val;Amanda Swain - 通讯作者:
Amanda Swain
09-P090 Retinoic acid is necessary and sufficient for the initiation of prostate development
- DOI:
10.1016/j.mod.2009.06.420 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Sarah Bryant;Amanda Swain - 通讯作者:
Amanda Swain
Protein kinase A drives paracrine crisis leading to WNT4-dependent germ cell loss and testis tumor in Carney complex
- DOI:
10.1016/j.ando.2022.09.012 - 发表时间:
2022-12-01 - 期刊:
- 影响因子:
- 作者:
Cyril Djari;Iabelle Sahut-Barnola;Constantine Stratakis;Hervé Lefèbvre;Florian Guillou;Amanda Swain;Antoine Martinez;Anne-Marie Lefrançois-Martinez - 通讯作者:
Anne-Marie Lefrançois-Martinez
Amanda Swain的其他文献
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{{ truncateString('Amanda Swain', 18)}}的其他基金
Identification of therapeutic sensitivities and pathways driving adrenocortical carcinoma
确定治疗敏感性和驱动肾上腺皮质癌的途径
- 批准号:
MR/N009916/1 - 财政年份:2016
- 资助金额:
$ 32.43万 - 项目类别:
Research Grant
Investigation into the role of HOX factors in gonad and adrenal steroidogenesis
HOX因子在性腺和肾上腺类固醇生成中的作用研究
- 批准号:
G0901645/1 - 财政年份:2010
- 资助金额:
$ 32.43万 - 项目类别:
Research Grant
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The role of ventromedial hypothalamic steroidogenic factor-1 neurons in exercise-related metabolism
下丘脑腹内侧类固醇生成因子1神经元在运动相关代谢中的作用
- 批准号:
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The role of ventromedial hypothalamic steroidogenic factor-1 neurons in exercise-related metabolism
下丘脑腹内侧类固醇生成因子1神经元在运动相关代谢中的作用
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Transcriptional regulation of the FSH-ß subunit by steroidogenic factor 1
类固醇生成因子 1 对 FSH-α 亚基的转录调节
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Transcriptional regulation of the inhibin B co-receptor by steroidogenic factor 1
类固醇生成因子 1 对抑制素 B 辅助受体的转录调节
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Studentship Programs
Identification of novel multicomponent protein complexes of the critical transcription factors Steroidogenic factor 1 and Liver Receptor Homolog 1 essential to embryonic stem cells and induced pluripotent stem cells
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NHMRC Project Grants
Regulation of follicle-stimulating hormone synthesis by steroidogenic factor-1 (SF1) and beta-catenin (CTNNB1)
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