CIMA (CASPASE-INDEPENDENT MITOTIC APOPTOSIS)

CIMA（不依赖CASPASE的有丝分裂凋亡）

• 批准号: 7358133
• 负责人: KATSUMI KITAGAWA
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358133
• 关键词: CIMA; CASPASE; INDEPENDENT; MITOTIC; APOPTOSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. CIMA (caspase-independent mitotic apoptosis) is a novel mitotic cell death that we have recently found. This cell death occurs when Bub1 (a spindle checkpoint protein kinase)- deficient cells have defects in the kinetochore-microtubule attachment. To define the morphological futures (particularly mitochondria) of this novel type of cell death, Kitigawa plans to perform transmission electron microscopy and electron tomography.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。 CIMA（不依赖半胱天冬酶的有丝分裂细胞凋亡）是我们最近发现的一种新型有丝分裂细胞死亡。当 Bub1（一种纺锤体检查点蛋白激酶）缺陷的细胞在动粒-微管附着处存在缺陷时，就会发生这种细胞死亡。为了确定这种新型细胞死亡的形态学前景（特别是线粒体），北川计划进行透射电子显微镜和电子断层扫描。