CIMA (CASPASE-INDEPENDENT MITOTIC APOPTOSIS)

CIMA（不依赖CASPASE的有丝分裂凋亡）

• 批准号: 7601061
• 负责人: KATSUMI KITAGAWA
• 金额: $ 0.22万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601061
• 关键词: Aneuploidy; Apoptosis; BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog; BUB1 gene; Caspase; Cell Death; Cells; Chromosomal Instability; Computer Retrieval of Information on Scientific Projects Database; Cultured Cells; Electron Microscopy; Funding; Grant; Institution; Mediating; Mitochondria; Mitotic; Research; Research Personnel; Resources; Source; Structure; System; United States National Institutes of Health; electron tomography; neoplastic cell; prevent; response; tumor; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In order to aid the study of mitochondrial structure, Dr. Perkins, who conducts electron microscopy and electron tomography on mitochondria, agreed to look at our treated cells. Little is known about the relationship between the spindle checkpoint and cell death or apoptosis. Many tumor cells have a diminished, but not absent, spindle checkpoint response. caspase-independent mitotic cell death (CIMCD) occurs when BUB1 function is partly but not completely disrupted as in chromosome instability (CIN) tumors. CIMCD may be an alternative system to prevent aneuploidy and, therefore, probably tumorigenesis when the BUB1-mediated activation of the spindle checkpoint fails. Dr. Perkins is providing a structural analysis of CIMCD in cultured cells, not only of mitochondria, but also of general cytoplasmic features.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 为了帮助线粒体结构的研究，Perkins博士，谁进行电子显微镜和电子断层扫描线粒体，同意看看我们处理的细胞。 关于纺锤体检查点与细胞死亡或凋亡之间的关系知之甚少。许多肿瘤细胞的纺锤体检查点反应减弱，但并非不存在。当BUB 1功能部分但不完全被破坏时，如在染色体不稳定性（CIN）肿瘤中，发生半胱天冬酶非依赖性有丝分裂细胞死亡（CIMCD）。CIMCD可能是一种替代系统，以防止非整倍体，因此，可能肿瘤发生时，BUB 1介导的激活纺锤体检查点失败。 Perkins博士正在提供CIMCD在培养细胞中的结构分析，不仅是线粒体，而且是一般细胞质特征。