OLIGOMERIC STATE OF ADIPOCYTE FATTY-ACID BINDING PROTEIN

脂肪细胞脂肪酸结合蛋白的寡聚态

• 批准号: 7357755
• 负责人: RICHARD GILLILAN
• 金额: $ 0.81万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357755
• 关键词: OLIGOMERIC; STATE; ADIPOCYTE; FATTY; ACID

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previously-solved crystal structure indicates that AFABP exists in the dimeric state in solution when no ligands are present. The configuration of the dimer is expected to change upon binding of the drug troglitazone or the endogenous ligand 15d-PGJ2. AFABP action is implicated in metabolic syndrome and the onset of diabetes in humans. We believe that changes in the oligomeric state should be visible in SAXS envelopes.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。先前的晶体结构表明，在不存在配体的情况下，AFABP在溶液中以二聚体的形式存在。当药物曲格列酮或内源性配体15d-PGJ2结合时，二聚体的构型有望改变。AFABP的作用与人类的代谢综合征和糖尿病的发病有关。我们认为，低聚物态的变化应该在SAXS包膜中可见。