BIOSAXS ESSENTIALS WORKSHOP

BIOSAXS 要点研讨会

• 批准号: 8363551
• 负责人: RICHARD GILLILAN
• 金额: $ 2.59万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363551
• 关键词: Computer software; Data; Data Quality; Funding; Grant; Methods; Molecular; National Center for Research Resources; Preparation; Principal Investigator; Process; Proteins; Publishing; Reporting; Research; Research Infrastructure; Resolution; Resources; Sampling; Shapes; Solutions; Source; Students; Surveys; Techniques; United States National Institutes of Health; base; beamline; cost; data modeling; experience; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BioSAXS is a solution-based x-ray scattering technique that can yield valuable structural information on biomolecules such as the size, low-resolution shape, degree of folding, and oligomeric state. This practical two-day course for molecular biologists will focus on collecting, processing, and publishing BioSAXS data. No previous x-ray experience necessary. Students will have the opportunity to collect data on CHESS beamlines using protein standards and/or their own samples. Processing software, installation help, and tutorials will be provided Course topics: basic principles and processing methods sample preparation tips evaluating data quality computing envelopes and data modeling reporting and statistics where BioSAXS is going: survey of new applications

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 BioSAXS 是一种基于溶液的 X 射线散射技术，可以产生有关生物分子的有价值的结构信息，例如大小、低分辨率形状、折叠程度和寡聚状态。 这个为期两天的实用分子生物学家课程将重点关注收集、处理和发布 BioSAXS 数据。 无需具备 X 光检查经验。 学生将有机会使用蛋白质标准品和/或他们自己的样本收集有关 CHESS 光束线的数据。 将提供处理软件、安装帮助和教程 课程主题： 基本原理及加工方法 样品制备技巧 评估数据质量 计算范围和数据建模 报告和统计 BioSAXS 的发展方向：新应用调查