METABOLIC CORRELATES OF FUNCTIONAL MRI: HIV NEUROCOGNITIVE IMPAIRMENT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目的总体目标是开发和验证一种同时测量脑血流量(CBF)和葡萄糖代谢的方法，该方法使用MRI和PET的多模式成像。最近在子项目0008、0053和0061中优化的动脉自旋标记(ASL)灌流技术被用于评估HIV相关的神经认知损害对尾状核血流和容量的影响。尾状核血流量和体积的减少趋势与HIV相关神经认知障碍(HNCI)的显著增加有关，观察到更严重的损害患者的下降幅度最大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to develop and validate a method for concurrent measurement of cerebral blood flow (CBF) and glucose metabolism using multimodal imaging with MRI and PET. Recently optimized arterial spin labeled (ASL) perfusion technique in subprojects 0008, 0053 and 0061 is used to evaluate the effects of HIV-associated neurocognitive impairment on caudate blood flow and volume. Decreasing trends in caudate blood flow and volume were associated with significantly increasing HIV-associated neurocognitive impairment (HNCI), with the greatest decreases observed for more severely impaired patients.