BRAIN PERFUSION IMAGING & FUNCTIONAL STUDIES: HIV NEUROCOGNITIVE IMPAIRMENT

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study concentrates on the development of new perfusion and brain functional imaging techniques for biomedical applications. The overall goal of this project is continued development arterial spin labeled (ASL) perfusion MRI for use in clinical applications including adult and pediatric stroke, peripheral vascular disease, and functional brain mapping. Recently optimized arterial spin labeled (ASL) perfusion technique in subprojects 0008, 0053 and 0061 is used to evaluate the effects of HIV-associated neurocognitive impairment on caudate blood flow and volume. Decreasing trends in caudate blood flow and volume were associated with significantly increasing HIV-associated neurocognitive impairment (HNCI), with the greatest decreases observed for more severely impaired patients.