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Nutritional regulation of adipose tissue blood flow in humans: dietary neural and structural determinants

人体脂肪组织血流的营养调节：饮食神经和结构决定因素

基本信息

批准号：
BB/D008123/1
负责人：
Keith Frayn
金额：
$ 42.18万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FD008123%2F1
关键词：
Nutritional regulation adipose tissue blood

项目摘要

Fat is stored on the wall of the abdomen and under the skin in other places on the body. Blood flows through these deposits of fat. We discovered recently that the flow of blood to the fat deposits can increase a lot just after a meal. But in some people the blood flow does not increase. These are people who are at increased risk of developing heart disease as judged from blood samples. This is similar to observations made on blood flowing through the big blood vessels in the arm. If you stop the blood flowing through the arm with a tourniquet for a few minutes, normally the blood then rushes back at an increased rate. It is already known that if someone's arm blood flow is 'unresponsive' when challenged in this way, then that person is at increased risk of developing heart disease. In this project we want to find out what makes the blood flow in fat increase after a meal, why it doesn't do that in some people, and whether we can alter that by changing someone's diet to a 'healthier' pattern. We think the nervous system probably regulates the blood flow and we will test whether that is so, and what is different in the people whose blood flow doesn't respond to meals. Then we can see if the nervous system responses are changed by a healthier diet. We will also use a syringe and needle to take little samples of the fatty tissue for examination under a microscope to try to understand what is different about the fat deposits in someone whose blood flow doesn't respond to meals. In the long term, this research may help explain why the functioning of blood vessels is related to risk of heart disease, and may help us to guide people with increased risk of heart disease towards healthier diets.

脂肪储存在腹壁上和身体其他部位的皮下。血液流过这些脂肪沉积物。我们最近发现，饭后流向脂肪沉积的血液会增加很多。但有些人的血流量不会增加。根据血液样本判断，这些人患心脏病的风险较高。这类似于对流经手臂大血管的血液进行的观察。如果用止血带阻止血液流过手臂几分钟，通常血液会以更快的速度回流。众所周知，如果某人的手臂血流在受到这种方式的挑战时“无反应”，那么该人患心脏病的风险就会增加。在这个项目中，我们想要找出是什么导致餐后脂肪中的血流量增加，为什么对某些人来说不会增加，以及我们是否可以通过将某人的饮食改变为“更健康”的模式来改变这种情况。我们认为神经系统可能调节血流，我们将测试是否如此，以及血流对膳食没有反应的人有何不同。然后我们可以看看更健康的饮食是否会改变神经系统的反应。我们还将使用注射器和针头采集少量脂肪组织样本，在显微镜下进行检查，以尝试了解血液流动对膳食没有反应的人的脂肪沉积有何不同。从长远来看，这项研究可能有助于解释为什么血管功能与心脏病风险相关，并可能帮助我们指导心脏病风险较高的人采取更健康的饮食。