What is the mechanism by which mammalian ribosomes are released from the mRNA following termination of translation?
What is the mechanism by which mammalian ribosomes are released from the mRNA following termination of translation?
批准号:
BB/D008190/1
负责人:
Richard Jackson
金额:
$39.35万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2006
资助国家:
英国
项目状态:
已结题
起止时间:
2006 至 --
中文摘要
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英文摘要
The strong physical, behavioural, and mental similarity of identical twins shows that it is our genetic material that largely specifies what we are. This genetic material is our DNA, which can be regarded as an exceedingly long 'tape' (e.g. an enormous video tape) with some 3 billion bits of information, coding for the numerous different types of protein which carry out most of our bodily functions. The DNA can be thought of as the 'master tape', an archive of thousands of normal length videos joined together. The process of decoding this information in the DNA involves first making a working copy of one of these videotapes in the archive. This is then decoded by a small particle known as a ribosome, which essentially carries out an analogous function to that of a video recorder (VCR) as it decodes the information as pictures. These 'biological videos' are similar to real videos in so far as the part of the tape with the pictorial information is preceded by a short leader length that has no information, and ends with a trailer that is likewise meaningless. We know that our biological VCR (the ribosome) finds the point where the true information starts by searching or scanning in fast-forward mode through the leader. However, when the ribosome-like VCR has reached the end of the pictorial information, it does not scan or try to read the meaningless trailer. Instead, as soon as the pictorial information has come to an end, the biological video is essentially ejected from the biological VCR. While we understand how this ejection mechanism works in the case of the bacterial 'VCR', we know absolutely nothing about how the mammalian eject mechanism works, except that it seems to be completely different from the bacterial mechanism. The aim of this project is to find out how the mammalian 'biological VCR' ejects the biological video cassette.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1371/journal.pone.0008390
发表时间:
2009-12-22
期刊:
PloS one
影响因子:
3.7
作者:
[Napthine S, Lever RA, Powell ML, Jackson RJ, Brown TD, Brierley I]
通讯作者:
Brierley I
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[M. Mathews;N. Sonenberg;J. Hershey]
通讯作者:
M. Mathews;N. Sonenberg;J. Hershey
DOI:
10.1371/journal.pone.0016822
发表时间:
2011-02-08
期刊:
PloS one
影响因子:
3.7
作者:
[Powell ML, Leigh KE, Pöyry TA, Jackson RJ, Brown TD, Brierley I]
通讯作者:
Brierley I
Detailed mapping of the sites of interaction of polypyrimidine tract binding protein with its RNA targets: viral and cellular IRESs and pre-mRNAs.
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批准号:BB/E004857/1
-
项目类别:Research Grant
-
资助金额:$36.48万
-
财政年份:2007
-
负责人:Richard Jackson
-
依托单位:
Capital Projects Technology Roadmap Integration Workshop; November 13-15, 2002; Leesburg, VA
-
批准号:0240690
-
项目类别:Standard Grant
-
资助金额:$2.0万
-
财政年份:2002
-
负责人:Richard Jackson
-
依托单位:
Nato Advanced Study Institute Travel Support Program to Summer School on Design and Implementation of Optimization Software, Sogesta, Italy, 06/20-07/02/77
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批准号:7712063
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项目类别:Standard Grant
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资助金额:$0.09万
-
财政年份:1977
-
负责人:Richard Jackson
-
依托单位:
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