What is the mechanism by which mammalian ribosomes are released from the mRNA following termination of translation?
翻译终止后,哺乳动物核糖体从 mRNA 中释放的机制是什么?
基本信息
- 批准号:BB/D008190/1
- 负责人:
- 金额:$ 39.35万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2006
- 资助国家:英国
- 起止时间:2006 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The strong physical, behavioural, and mental similarity of identical twins shows that it is our genetic material that largely specifies what we are. This genetic material is our DNA, which can be regarded as an exceedingly long 'tape' (e.g. an enormous video tape) with some 3 billion bits of information, coding for the numerous different types of protein which carry out most of our bodily functions. The DNA can be thought of as the 'master tape', an archive of thousands of normal length videos joined together. The process of decoding this information in the DNA involves first making a working copy of one of these videotapes in the archive. This is then decoded by a small particle known as a ribosome, which essentially carries out an analogous function to that of a video recorder (VCR) as it decodes the information as pictures. These 'biological videos' are similar to real videos in so far as the part of the tape with the pictorial information is preceded by a short leader length that has no information, and ends with a trailer that is likewise meaningless. We know that our biological VCR (the ribosome) finds the point where the true information starts by searching or scanning in fast-forward mode through the leader. However, when the ribosome-like VCR has reached the end of the pictorial information, it does not scan or try to read the meaningless trailer. Instead, as soon as the pictorial information has come to an end, the biological video is essentially ejected from the biological VCR. While we understand how this ejection mechanism works in the case of the bacterial 'VCR', we know absolutely nothing about how the mammalian eject mechanism works, except that it seems to be completely different from the bacterial mechanism. The aim of this project is to find out how the mammalian 'biological VCR' ejects the biological video cassette.
同卵双胞胎在身体、行为和心理上的强烈相似性表明,是我们的遗传物质在很大程度上决定了我们是什么。这种遗传物质就是我们的DNA,它可以被视为一盘非常长的‘磁带’(例如一盘巨大的录像带),其中包含大约30亿比特的信息,编码着许多不同类型的蛋白质,这些蛋白质执行我们的大部分身体功能。DNA可以被认为是“母带”,一个由数千个正常长度的视频连接在一起的档案。对DNA中的这些信息进行解码的过程包括首先制作档案中其中一盘录像带的工作副本。然后被称为核糖体的小颗粒解码,核糖体基本上执行类似于录像机(VCR)的功能,因为它将信息解码为图片。这些“生物视频”与真实视频的相似之处在于,录像带中含有图片信息的部分前面有一小段没有信息的前导,结尾的预告片也同样没有意义。我们知道,我们的生物VCR(核糖体)通过先导以快进模式搜索或扫描,找到真正信息的起始点。然而,当核糖体状的VCR到达图像信息的末尾时,它不会扫描或尝试阅读无意义的预告片。取而代之的是,一旦图像信息结束,生物视频基本上就从生物录像机中弹出。虽然我们了解这种喷射机制在细菌VCR的情况下是如何工作的,但我们对哺乳动物的喷射机制是如何工作的完全一无所知,除了它似乎与细菌的机制完全不同。这个项目的目的是找出哺乳动物的生物录像机是如何弹出生物录像带的。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Expression of the VP2 protein of murine norovirus by a translation termination-reinitiation strategy.
- DOI:10.1371/journal.pone.0008390
- 发表时间:2009-12-22
- 期刊:
- 影响因子:3.7
- 作者:Napthine S;Lever RA;Powell ML;Jackson RJ;Brown TD;Brierley I
- 通讯作者:Brierley I
Translational control in biology and medicine
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:M. Mathews;N. Sonenberg;J. Hershey
- 通讯作者:M. Mathews;N. Sonenberg;J. Hershey
Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA.
- DOI:10.1371/journal.pone.0016822
- 发表时间:2011-02-08
- 期刊:
- 影响因子:3.7
- 作者:Powell ML;Leigh KE;Pöyry TA;Jackson RJ;Brown TD;Brierley I
- 通讯作者:Brierley I
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Richard Jackson其他文献
Neurodevelopmental outcomes at 2 years in children who received sildenafil therapy in utero: The STRIDER randomised controlled trial
在子宫内接受西地那非治疗的儿童 2 岁时的神经发育结果:STRIDER 随机对照试验
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Andrew Sharp;Christine Cornforth;Richard Jackson;Jane Harrold;Mark A. Turner;Louise C. Kenny;Philip N. Baker;Edward D. Johnstone;Asma Khalil;Peter von Dadelszen;Aris T. Papageorghiou;Zarko Alfirevic;Brigitte Vollmer - 通讯作者:
Brigitte Vollmer
Dental caries diagnosis.
龋齿诊断。
- DOI:
- 发表时间:
1999 - 期刊:
- 影响因子:0
- 作者:
G. Stookey;Richard Jackson;A. Zandona;M. Analoui - 通讯作者:
M. Analoui
Developing Team Communication Skills in a Fast-Paced Interprofessional Learning Activity
- DOI:
10.1016/j.xjep.2015.07.050 - 发表时间:
2015-06-01 - 期刊:
- 影响因子:
- 作者:
Laura Romito;Richard Jackson;Lisa Maxwell;Carol Clark;Susan Hendricks;Beth Townsend;Mary Mueller;Julie A. Poore;Heather A. McCabe;Gaylen Kelton - 通讯作者:
Gaylen Kelton
The histological yield of 50 consecutive Thy 3- and Thy 4 thyroid nodules
- DOI:
10.1016/j.ejso.2017.10.039 - 发表时间:
2017-12-01 - 期刊:
- 影响因子:
- 作者:
Richard Jackson;Stuart Burrows - 通讯作者:
Stuart Burrows
Rigid versus flexible endoscopy for managing ingested foreign bodies—can we improve pathways?
- DOI:
10.1007/s00405-022-07285-y - 发表时间:
2022-02-05 - 期刊:
- 影响因子:2.200
- 作者:
Richard Jackson;Emilien Chabrillac;Alexandra Bell;Ovie Edafe - 通讯作者:
Ovie Edafe
Richard Jackson的其他文献
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{{ truncateString('Richard Jackson', 18)}}的其他基金
Detailed mapping of the sites of interaction of polypyrimidine tract binding protein with its RNA targets: viral and cellular IRESs and pre-mRNAs.
聚嘧啶束结合蛋白与其 RNA 靶标(病毒和细胞 IRES 和前 mRNA)相互作用位点的详细图谱。
- 批准号:
BB/E004857/1 - 财政年份:2007
- 资助金额:
$ 39.35万 - 项目类别:
Research Grant
Capital Projects Technology Roadmap Integration Workshop; November 13-15, 2002; Leesburg, VA
资本项目技术路线图集成研讨会;
- 批准号:
0240690 - 财政年份:2002
- 资助金额:
$ 39.35万 - 项目类别:
Standard Grant
Nato Advanced Study Institute Travel Support Program to Summer School on Design and Implementation of Optimization Software, Sogesta, Italy, 06/20-07/02/77
北约高级研究所针对优化软件设计和实施暑期学校的旅行支持计划,意大利索杰斯塔,06/20-07/02/77
- 批准号:
7712063 - 财政年份:1977
- 资助金额:
$ 39.35万 - 项目类别:
Standard Grant
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