SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
基本信息
- 批准号:7369042
- 负责人:
- 金额:$ 0.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-03-01 至 2007-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Imaging contrast agents (or contrast media) are a category of diagnostic pharmaceuticals for enhancing the image contrast of organs/tissues and for displaying the organ function in medical imaging. Macromolecular contrast agents have found their important role in the characterization of microvascular permeability of tumor vessels, due to their blood-pool characteristics. New dendritic contrast agents with well-defined structure, high degree of size homogeneity, varying molecular weights and polyethyleneglycol (PEG) cores, will be synthesized. Their average molecular weights (MW) and MW distribution will be obtained from mass spectrometry, which info will be highly helpful for the chemical synthesis and for the study of their structure-property relationship. In addition, some new small molecular intermediates, which are attributed to the image contrast, need the structure characterization by mass spectrometry, too. Methods: For different macromolecular derivatives (MW 3,000 - 150,000), MALDI-MS could be used for the measurements of their MW and distributions in MW. For small molecular compounds (MW 500 - 2000), ESI-MS or other approaches may be applicable. Results & Discussion: Mass spectra data will be correlated with the data from physical and imaging measurements, the relationship between chemical structure and physical (or imaging) properties will be sought for this new class of macromolecular contrast agents. During the synthesis, the mass spectra data will be highly helpful in the guidance and optimization of synthetic procedures.
本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者(PI)可能已经从另一个NIH来源获得了主要资金,因此可以在其他CRISP条目中表示。列出的机构是中心的,不一定是研究者的机构。简介:成像造影剂(或造影剂)是医学成像中用于增强器官/组织图像对比度和显示器官功能的一类诊断药物。由于大分子造影剂的血池特性,它们在肿瘤血管微血管通透性的表征中发挥了重要作用。新型树突状造影剂具有良好的结构,高度的尺寸均匀性,不同的分子量和聚乙二醇(PEG)核,将被合成。通过质谱分析得到它们的平均分子量(MW)和分子量分布,为化学合成和研究它们的构效关系提供了重要的信息。此外,一些新的小分子中间体,由于图像对比,也需要用质谱法进行结构表征。方法:对于不同的大分子衍生物(分子量为3000 ~ 150000),MALDI-MS可用于测定其分子量及其在分子量中的分布。对于小分子化合物(MW 500 - 2000), ESI-MS或其他方法可能适用。结果与讨论:质谱数据将与物理和成像测量数据相关联,化学结构与物理(或成像)性能之间的关系将寻求这类新型大分子造影剂。在合成过程中,质谱数据将对合成过程的指导和优化有很大的帮助。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert Charles Brasch的其他文献
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{{ truncateString('Robert Charles Brasch', 18)}}的其他基金
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
8363734 - 财政年份:2011
- 资助金额:
$ 0.02万 - 项目类别:
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
8169728 - 财政年份:2010
- 资助金额:
$ 0.02万 - 项目类别:
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
7957365 - 财政年份:2009
- 资助金额:
$ 0.02万 - 项目类别:
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
7724164 - 财政年份:2008
- 资助金额:
$ 0.02万 - 项目类别:
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
7601814 - 财政年份:2007
- 资助金额:
$ 0.02万 - 项目类别:
SYNTHESIS & CHARACTERIZATION OF NEW MACROMOLECULAR CONTRAST AGENTS
合成
- 批准号:
7180926 - 财政年份:2005
- 资助金额:
$ 0.02万 - 项目类别:
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