POLARIZED ION TRANSPORT DURING TIP GROWTH AND DIRECTED CELL MOTILITY

尖端生长和定向细胞运动期间的极化离子传输

• 批准号: 7357359
• 负责人: MARK A MESSERLI
• 金额: $ 2.45万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357359
• 关键词: POLARIZED; ION; TRANSPORT; DURING; TIP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tip growth and cell motility are highly directed forms of cellular motion. Tip growth is a form of polarized growth where exocytosis, leading to cell expansion, occurs at a single localized site, giving rise to long cylindrical or conical structures. Invasion by many pathogenic fungi and reproduction of higher plants is dependent on tip growth. Cell motility on the other hand involves migration of the entire cell. Many types of cells are able to migrate, including supporting glia of the nervous system, macrophages of the immune system and cancer cells. Both tip growth and cell motility can be directed by external cues to guide a population of cells that would normally grow/move in random directions. Our research has focused on the ionic control and signal transduction pathways that direct normal tip growth and cell motility and during the imposition of external guidance cues.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尖端生长和细胞运动是高度定向的细胞运动形式。尖端生长是极化生长的一种形式，其中胞吐作用导致细胞扩张，在单个局部位置发生，产生长长的圆柱形或圆锥形结构。许多病原真菌的入侵和高等植物的繁殖依赖于顶端的生长。另一方面，细胞运动涉及整个细胞的迁移。许多类型的细胞能够迁移，包括神经系统的支持胶质细胞、免疫系统的巨噬细胞和癌细胞。尖端的生长和细胞的运动都可以由外部线索来指导，以引导正常情况下会以随机方向生长/移动的细胞群体。我们的研究集中在离子控制和信号转导通路上，这些通路引导正常的尖端生长和细胞运动，并在施加外部指导线索期间进行。