POLARIZED ION TRANSPORT DURING TIP GROWTH AND DIRECTED CELL MOTILITY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。尖端生长和细胞运动是细胞运动的高度定向形式。尖端生长是一种极化生长形式，细胞外吐导致细胞扩张，发生在单个局部位置，产生长圆柱形或圆锥形结构。许多病原真菌的入侵和高等植物的繁殖都依赖于茎尖的生长。另一方面，细胞运动涉及整个细胞的迁移。许多类型的细胞都能够迁移，包括支持神经系统的胶质细胞、免疫系统的巨噬细胞和癌细胞。尖端生长和细胞运动都可以通过外部线索来引导通常会随机生长/移动的细胞群。我们的研究主要集中在离子控制和信号转导途径，这些途径指导正常尖端生长和细胞运动，以及在外部引导线索的施加过程中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tip growth and cell motility are highly directed forms of cellular motion. Tip growth is a form of polarized growth where exocytosis, leading to cell expansion, occurs at a single localized site, giving rise to long cylindrical or conical structures. Invasion by many pathogenic fungi and reproduction of higher plants is dependent on tip growth. Cell motility on the other hand involves migration of the entire cell. Many types of cells are able to migrate, including supporting glia of the nervous system, macrophages of the immune system and cancer cells. Both tip growth and cell motility can be directed by external cues to guide a population of cells that would normally grow/move in random directions. Our research has focused on the ionic control and signal transduction pathways that direct normal tip growth and cell motility and during the imposition of external guidance cues.