NEURONAL GLUCOSE DETECTION & HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。强化胰岛素治疗是预防所有I型糖尿病患者和许多2型糖尿病患者高血糖诱导损害的唯一方法。然而，胰岛素治疗会产生危及生命的副作用-低血糖。此外，即使低血糖发作一次，大脑也无法检测到未来的低血糖发作。这种综合征，统称为低血糖相关自主神经功能衰竭（HAAF）和低血糖无意识，使血糖水平下降到严重，甚至致命的水平，而不被发现。我们的目标是了解大脑感知葡萄糖的能力如何在导致HAAF的复发性低血糖期间受损。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Intensive insulin therapy is the only way to prevent hyperglycemia-induced damage in all patients with Type I, and many with Type 2, Diabetes Mellitus. However, insulin therapy produces a life-threatening side effect ¿ hypoglycemia. Moreover, even on bout of hypoglycemia renders the brain unable to detect future hypoglycemia episodes. This syndrome, known collectively as hypoglycemia-associated autonomic failure (HAAF) and hypoglycemia unawareness, allows blood glucose levels to fall to severe, even lethal, levels without detection. It is our goal to understand how the brain¿s ability to sense glucose becomes impaired during recurrent hypoglycemia leading to HAAF.