NEURONAL GLUCOSE DETECTION & HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE

神经元葡萄糖检测

• 批准号: 7721112
• 负责人: VANESSA H ROUTH
• 金额: $ 1.13万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721112
• 关键词: Adverse effects; Blood Glucose; Brain; Computer Retrieval of Information on Scientific Projects Database; Detection; Failure; Funding; Future; Glucose; Goals; Grant; Hyperglycemia; Hypoglycemia; Institution; Insulin; Life; Neurons; Non-Insulin-Dependent Diabetes Mellitus; Patients; Recurrence; Research; Research Personnel; Resources; Source; Syndrome; United States National Institutes of Health; falls; hypoglycemia unawareness; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Intensive insulin therapy is the only way to prevent hyperglycemia-induced damage in all patients with Type I, and many with Type 2, Diabetes Mellitus. However, insulin therapy produces a life-threatening side effect  hypoglycemia. Moreover, even on bout of hypoglycemia renders the brain unable to detect future hypoglycemia episodes. This syndrome, known collectively as hypoglycemia-associated autonomic failure (HAAF) and hypoglycemia unawareness, allows blood glucose levels to fall to severe, even lethal, levels without detection. It is our goal to understand how the brain's ability to sense glucose becomes impaired during recurrent hypoglycemia leading to HAAF.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 强化胰岛素治疗是防止所有I型患者和许多患有2型糖尿病的患者造成高血糖诱导的损害的唯一方法。但是，胰岛素治疗会产生威胁生命的副作用低血糖症。此外，即使在低血糖爆发时，大脑也无法检测未来的低血糖发作。该综合征统称为低血糖相关的自主衰竭（HAAF）和低血糖不认识，使血糖水平降至严重，甚至致命的水平，而无需检测。我们的目标是了解大脑在复发性低血糖症期间如何感知葡萄糖的能力会受到损害。