VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS

委内瑞拉马脑脊髓炎病毒

• 批准号: 7357776
• 负责人: Stanley J Watowich
• 金额: $ 0.75万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357776
• 关键词: VENEZUELAN; EQUINE; ENCEPHALOMYELITIS; VIRUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to determine intermolecular interactions that regulate the concerted assembly of Venezuelan equine encephalitis virus (VEEV), an alphavirus that causes epidemics in the Central and South America, and a highly developed biological weapons agent without effective therapy. Aim 1. To determine interactions between the VEE virus capsid protein and RNA that promote viral nucleocapsid assembly, using complementary biochemical, biophysical, molecular and structural biology approaches. Aim 2. To determine if intermolecular capsid protein interactions within the nucleocapsid undergo large-scale rearrangements during VEE virus maturation by determining the structure of pre-viral, viral, and post-viral nucleocapsids.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的目标是确定调节委内瑞拉马脑炎病毒（VEEV）协同组装的分子间相互作用，这是一种在中美洲和南美洲引起流行病的甲病毒，也是一种高度发达的生物武器制剂，但没有有效的治疗方法。目标1.使用互补的生化、生物物理、分子和结构生物学方法确定VEE病毒衣壳蛋白和RNA之间促进病毒核衣壳组装的相互作用。目标2.通过测定病毒前、病毒和病毒后核衣壳的结构，确定核衣壳内的分子间衣壳蛋白相互作用是否在VEE病毒成熟期间发生大规模重排。