IDENTIFICATION OF PROTEIN COMPLEXES AND PHOSPHORYLATION SITES OF PROTEINS REQUI

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The McCollum lab studies a signaling pathway in the fission yeast S. pombe, termed the septation initiation network (SIN), which functions at the end of mitosis to trigger initiation of cytokinesis. The components of the SIN localize to the spindle pole body (SPB). The Sid2p kinase and Mob1p form a complex and function at the end of the pathway to transmit a signal from the SPB to the cell division site to trigger initiation of cytokinesis. We will study the regulation of Sid2p and Mob1p.