IDENTIFICATION OF PROTEIN COMPLEXES AND PHOSPHORYLATION SITES OF PROTEINS REQUI

蛋白质复合物和蛋白质磷酸化位点的鉴定需要

• 批准号: 7420801
• 负责人: DANNEL MCCOLLUM
• 金额: $ 0.29万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420801
• 关键词: cell cycle; phosphorylation; proteins

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The McCollum lab studies a signaling pathway in the fission yeast S. pombe, termed the septation initiation network (SIN), which functions at the end of mitosis to trigger initiation of cytokinesis. The components of the SIN localize to the spindle pole body (SPB). The Sid2p kinase and Mob1p form a complex and function at the end of the pathway to transmit a signal from the SPB to the cell division site to trigger initiation of cytokinesis. We will study the regulation of Sid2p and Mob1p.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。 McCollum 实验室研究了裂殖酵母中的信号通路，称为分隔启动网络 (SIN)，它在有丝分裂结束时发挥作用，触发胞质分裂的启动。 SIN 的组件位于主轴极体 (SPB) 上。 Sid2p 激酶和 Mob1p 形成复合物，并在通路末端发挥作用，将信号从 SPB 传递到细胞分裂位点，从而触发胞质分裂的启动。我们将研究Sid2p和Mob1p的调控。