DYNAMICS OF THE CONTRACTILE RING FILAMENT NETWORK DURING CYTOKINESIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytokinesis completes cell division, ensuring the generation of two daughter cells that contain a single genomic complement. In animal cells, cytokinesis requires the constriction of a cortical contractile ring that assembles around the cell equator during anaphase. The structural components of the ring include three protein polymer systems: actin, myosin II, and the septins. The organization and mechanism of constriction of the contractile ring remain poorly understood. I propose to use the C. elegans embryo as a model system to analyze the distribution, dynamic properties and functional interactions between the three polymer systems during ring constriction.