WORD AND SHAPE SENSITIVITY IN OCCIPITO-TEMPORAL CORTEX OF ADULTS AND CHILDREN

成人和儿童枕颞皮层的单词和形状敏感性

• 批准号: 7358823
• 负责人: MICHAEL BEN-SHACHAR
• 金额: $ 0.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358823
• 关键词: WORD; SHAPE; SENSITIVITY; OCCIPITO; TEMPORAL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Efficient extraction of shape information is essential for proficient reading. A heated debate concerns the question: is there a specialized system for processing visual word forms? We study this topic in two ways: (a) correlating fMRI signals for word processing with reading skills in children. (b) comparing fMRI visibility curves for words and other shapes such as line drawings and false fonts. Our analysis focuses on the occipito-temporal sulcus (OTS), a region hypothesized to specialize in visual word forms (Cohen et al., 2000). Methods: Nine adults (ages 23-53) and fifty children (ages 7-12) participated in four testing sessions, including neuropsychological assessment (children only), high resolution MRI, DTI and functional MRI scans. MRI scans were performed in the Lucas Center at Stanford University. In fMRI we presented visual words masked by phase-scrambled noise, while subjects were engaged in a fixation judgment task. Noise level was manipulated parametrically, resulting in 4 activation conditions, which were interleaved with fixation blocks. Adults were also presented with line drawings and false font strings in different sessions using the same paradigm. Functional data were acquired using a 3T signa GE scanner, with spiral acquisition. 26 oblique slices (3x3x3 mm), TR=2000.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。有效的形状信息提取是熟练阅读的必要条件。一场激烈的辩论围绕着这样一个问题：是否存在一个专门处理视觉文字形式的系统？我们从两个方面研究了这一主题：(a)将单词处理与儿童阅读技能的fMRI信号相关联。(b)比较单词和其他形状（如线条图和虚假字体）的fMRI可见性曲线。我们的分析集中在枕颞沟（OTS）上，这是一个假设专门用于视觉词形式的区域（Cohen et al., 2000）。方法：9名成人（23-53岁）和50名儿童（7-12岁）参加了4个测试，包括神经心理评估（仅限儿童）、高分辨率MRI、DTI和功能MRI扫描。MRI扫描在斯坦福大学卢卡斯中心进行。在功能磁共振成像中，我们呈现了被相位打乱噪声掩盖的视觉单词，同时受试者进行注视判断任务。对噪声水平进行参数化处理，得到4种激活条件，这些条件与固定块相互交错。在不同的会话中，使用相同的范式，成年人也看到了线条图和错误的字体字符串。功能数据采集采用3T信号GE扫描仪，螺旋采集。26片斜片（3x3x3 mm）， TR=2000。