NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
基本信息
- 批准号:7358832
- 负责人:
- 金额:$ 0.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-06-01 至 2007-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Depression is a widely diagnosed and highly debilitating disorder. Cognitive theories of depression posit that depressed individuals are characterized by cognitive biases favoring in the processing of negative affective information. An information-processing bias frequently associated with major depression is increased memory sensitivity for negative information and, often, decreased memory sensitivity for positive material. Importantly, the amygdala has been centrally implicated in encoding and memory for emotionally valenced material and has been found to show elevated resting state activity in depression. The primary goal of this study is to assess the role of amygdalar activation in the negative memory bias associated with depression. Methods and Results: Ten participants meeting criteria for major depressive disorder in the absence of other Axis-I disorders and ten age and sex-matched healthy control participants served as participants in this study. Functional magnetic resonance imaging (fMRI) was used to measure neural activation during presentation and affective evaluation of positive, neutral and negative pictures. One week following scanning, participants engaged in an out-of-scanner recognition memory task during which they were presented with pictures that they saw in the scanner and with never-seen pictures, and were asked to rate the familiarity of each picture. Memory sensitivity for negative pictures was significantly higher in depressed than in control participants; the two groups of participants did not differ in memory sensitivity for positive pictures. Corresponding to this finding, activity in the left amygdala was significantly higher during encoding of subsequently remembered negative pictures in depressed than in control participants, but not during encoding of neutral or positive pictures.
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是针对中心的,而不一定是针对调查员的机构。背景:抑郁症是一种被广泛诊断的高度衰弱的疾病。抑郁的认知理论认为,抑郁个体的特征是在加工负面情感信息时存在认知偏差。与重度抑郁症相关的信息处理偏差经常是对负面信息的记忆敏感度增加,而对积极材料的记忆敏感度往往降低。重要的是,杏仁核与情感配价物质的编码和记忆密切相关,并被发现在抑郁症患者的静息状态下活动增加。这项研究的主要目的是评估杏仁核激活在与抑郁症相关的负面记忆偏差中的作用。方法和结果:10名符合严重抑郁障碍标准且无其他轴-I障碍的参与者和10名年龄和性别匹配的健康对照组参与者作为研究参与者。用功能磁共振成像(FMRI)测量正性、中性和负性图片呈现和情感评价过程中的神经激活情况。扫描一周后,参与者参与了一项扫描仪外识别记忆任务,在此过程中,他们被呈现给他们在扫描仪中看到的图片和从未见过的图片,并被要求对每一张图片的熟悉度进行评级。抑郁受试者对负性图片的记忆敏感性显著高于对照组;两组受试者对正面图片的记忆敏感性没有差异。与这一发现相对应的是,抑郁症患者在编码随后记住的负面图片时,左侧杏仁核的活动显著高于对照组,但在编码中性或正面图片时则没有。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Lawrence Hamilton其他文献
Paul Lawrence Hamilton的其他文献
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{{ truncateString('Paul Lawrence Hamilton', 18)}}的其他基金
INVESTIGATING NEURAL PRIMACY IN MAJOR DEPRESSIVE DISORDER
调查重度抑郁症的神经首要性
- 批准号:
8362971 - 财政年份:2011
- 资助金额:
$ 0.31万 - 项目类别:
NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
- 批准号:
8362898 - 财政年份:2011
- 资助金额:
$ 0.31万 - 项目类别:
NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
- 批准号:
8169830 - 财政年份:2010
- 资助金额:
$ 0.31万 - 项目类别:
NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
- 批准号:
7955356 - 财政年份:2009
- 资助金额:
$ 0.31万 - 项目类别:
REAL-TIME LOCALIZED NEUROMODULATION IN MAJOR DEPRESSION
重度抑郁症的实时局部神经调节
- 批准号:
7722872 - 财政年份:2008
- 资助金额:
$ 0.31万 - 项目类别:
NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
- 批准号:
7722871 - 财政年份:2008
- 资助金额:
$ 0.31万 - 项目类别:
REAL-TIME LOCALIZED NEUROMODULATION IN MAJOR DEPRESSION
重度抑郁症的实时局部神经调节
- 批准号:
7601897 - 财政年份:2007
- 资助金额:
$ 0.31万 - 项目类别:
NEURAL SUBSTRATES OF MEMORY SENSITIVITY FOR NEGATIVE STIMULI IN DEPRESSION
抑郁症中记忆对负面刺激敏感的神经基础
- 批准号:
7601896 - 财政年份:2007
- 资助金额:
$ 0.31万 - 项目类别:
REAL-TIME LOCALIZED NEUROMODULATION IN MAJOR DEPRESSION
重度抑郁症的实时局部神经调节
- 批准号:
7358833 - 财政年份:2006
- 资助金额:
$ 0.31万 - 项目类别:
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