Alcohol Phenotype Development in American Samoa

美属萨摩亚的酒精表型发展

基本信息

  • 批准号:
    7314144
  • 负责人:
  • 金额:
    $ 23.62万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-08-05 至 2009-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The major purpose of this Exploratory/Developmental proposal is to lay the groundwork for a study of the genetics of alcohol dependence in Samoans. The indigenous Polynesians of American Samoa constitute an isolated population that have a high prevalence of obesity and related illnesses, such as diabetes. Ongoing research conducted by one of us (STM) in collaboration with the assistance of local Samoan health officials, is attempting to identify behavioral and genetic factors associated with these problems. DNA and obesity phenotype information has been collected on more than 1100 individuals. There are many commonalities in the neurobiological control of behaviors associated with food consumption and alcohol consumption. Our preliminary research suggests that heavy alcohol use and alcohol use disorders are present in Samoans at a high prevalence. However, little information is available about alcohol diagnoses, quantity and frequency of alcohol drinking, and the presence of alcohol-related traits, behaviors and consequences in this population. The specific aims are to develop assessment methodology to identify alcohol-related diagnoses, traits and behaviors which may be representative of alcohol-related endophenotypes in Samoans. Alcohol diagnoses will be defined according to DSM-IV diagnostic criteria, using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Alcohol-related traits, such as drunkenness, family history of substance use disorders, craving, and drinking patterns, etc. will be assessed with additional questionnaires, including the Family History Assessment Module, the Self-rating of the Effects of Alcohol Scale, and the Food Craving Inventory that will be adapted for use in this population by a formal qualitative and quantative development process. Assessments will be translated into the Samoan language, will utilize culturally appropriate procedures and will be administered by trained interviewers. We will also utilize behavioral testing to assess the potential endophenotypes of sweet preference, risk taking, and cue-induced alcohol craving in the participants.
描述(由申请人提供):这项探索性/发展性建议的主要目的是为研究萨摩亚人酒精依赖的遗传学奠定基础。美属萨摩亚的土著波利尼西亚人是一个与世隔绝的群体,肥胖症和糖尿病等相关疾病的发病率很高。我们中的一人(STM)在萨摩亚当地卫生官员的协助下正在进行的研究,正试图确定与这些问题有关的行为和遗传因素。已经收集了1100多个个体的DNA和肥胖表型信息。在与食物和酒精消费相关的行为的神经生物学控制方面有许多共同点。我们的初步研究表明,重度酒精使用和酒精使用障碍在萨摩亚人中存在很高的流行率。然而,关于酒精诊断、饮酒量和饮酒频率以及该人群中与酒精相关的特征、行为和后果的信息很少。具体目的是开发评估方法,以确定与酒精有关的诊断、特征和行为,这些诊断、特征和行为可能代表萨摩亚人与酒精相关的内表型。酒精诊断将根据DSM-IV诊断标准,使用药物依赖和酒精中毒半结构化评估(SSADDA)进行定义。与酒精有关的特征,如醉酒、物质使用障碍家族史、渴求和饮酒模式等,将通过额外的问卷进行评估,包括家族史评估模块、酒精影响自评量表和食物渴望问卷,这些问卷将通过正式的定性和定量发展过程进行调整,以适用于这一人群。评估将被翻译成萨摩亚语,将利用文化上适当的程序,并将由训练有素的面谈人员进行管理。我们还将利用行为测试 评估参与者的甜食偏好、冒险行为和线索诱导的酒精渴求的潜在内在表型。

项目成果

期刊论文数量(0)
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ROBERT M SWIFT其他文献

ROBERT M SWIFT的其他文献

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{{ truncateString('ROBERT M SWIFT', 18)}}的其他基金

Aripiprazole and Topiramate on Free-Choice Alcohol Use
阿立哌唑和托吡酯对自由选择饮酒的影响
  • 批准号:
    7496632
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Aripiprazole and Topiramate on Free-Choice Alcohol Use
阿立哌唑和托吡酯对自由选择饮酒的影响
  • 批准号:
    8102027
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Aripiprazole and Topiramate on Free-Choice Alcohol Use
阿立哌唑和托吡酯对自由选择饮酒的影响
  • 批准号:
    7644564
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Aripiprazole and Topiramate on Free-Choice Alcohol Use
阿立哌唑和托吡酯对自由选择饮酒的影响
  • 批准号:
    7318710
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Alcohol Phenotype Development in American Samoa
美属萨摩亚的酒精表型发展
  • 批准号:
    7479864
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Aripiprazole and Topiramate on Free-Choice Alcohol Use
阿立哌唑和托吡酯对自由选择饮酒的影响
  • 批准号:
    7881539
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
Device for Acamprosate Transcutaneous Delivery to Reduce Alcohol Consumption.
用于减少酒精消耗的阿坎酸经皮输送装置。
  • 批准号:
    7157433
  • 财政年份:
    2006
  • 资助金额:
    $ 23.62万
  • 项目类别:
MEDICATION/PSYCHOTHERAPY TAILORED TO PATIENT RESOURCES
针对患者资源量身定制的药物/心理治疗
  • 批准号:
    6168657
  • 财政年份:
    1997
  • 资助金额:
    $ 23.62万
  • 项目类别:
MEDICATION/PSYCHOTHERAPY TAILORED TO PATIENT RESOURCES
针对患者资源量身定制的药物/心理治疗
  • 批准号:
    6371471
  • 财政年份:
    1997
  • 资助金额:
    $ 23.62万
  • 项目类别:
MEDICATION/PSYCHOTHERAPY TAILORED TO PATIENT RESOURCES
针对患者资源量身定制的药物/心理治疗
  • 批准号:
    6533593
  • 财政年份:
    1997
  • 资助金额:
    $ 23.62万
  • 项目类别:

相似海外基金

Alcohol Phenotype Development in American Samoa
美属萨摩亚的酒精表型发展
  • 批准号:
    7479864
  • 财政年份:
    2007
  • 资助金额:
    $ 23.62万
  • 项目类别:
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