ASSESSMENT OF ALCOHOL CONSUMPTION BY TRANSDERMAL ETHANOL

长期饮酒的可靠测量方法是 对于研究应用、监测治疗结果和 法医应用已经开发了各种方法， 评估酒精消耗，包括口头报告，生化标志物， 以及直接测量血液、尿液和其他体液， 汗水然而，没有一种方法可以简单可靠地 确定长期饮酒的数量和模式。 一种原型设备，透皮酒精传感器（TAS）， 开发了使用透皮乙醇的电化学检测， 以短时间间隔重复采样乙醇浓度，固体- 将数据存储数天至数周，以监测乙醇 消费对照组饮酒量的初步研究 设置指示TAS能够确定模式， 以半定量的方式测量酒精的相对消耗量。的 TAS设备显示出良好的灵敏度，阈值检测低至10 - 100 μ m。 20毫克/分升。 该提案包括三项研究，将评估 TAS作为研究工具，以更好地了解酒精的各个方面 人类的消费。我们将使用TAS：（l）更好地了解 经皮乙醇在一系列个体中的药代动力学 在种族、性别和皮肤状况上不同，并对该设备进行试点测试 在已知饮酒量的条件下， 在家庭环境中;（2）在非酒精性饮酒者的现场试验中， 自然的饮酒条件;和3）与酗酒者在门诊 治疗我们将评估TAS器械的实用性和可接受性， 将其评估酒精消费的能力与传统的 评估措施，如自我报告、附属报告和 临床评估。

The reliable measurement of alcohol consumption over long time periods is important for research applications, monitoring treatment outcome and for forensic applications. A variety of methodologies have been developed to assess alcohol consumption, including verbal report, biochemical markers, and direct measurement of blood, urine and other body fluids such as sweat. Yet, no single method exists which can easily and reliably determine the amount and pattern of alcohol consumption over long periods. A prototype device, the Transdermal Alcohol Sensor (TAS) has been developed which uses electrochemical detection of transdermal ethanol, repeated sampling of ethanol concentration at short intervals, and solid- state storage of the data for periods of days to weeks to monitor ethanol consumption. Preliminary studies on alcohol consumption in controlled settings indicate that the TAS is capable of determining the pattern and relative amount of alcohol consumption in a semi-quantitative fashion. The TAS device shows good sensitivity with-threshold detection as low as 10 - 20 mg/dl. This proposal consists of three studies which will evaluate the use of the TAS as a research tool to better understand various aspects of alcohol consumption in humans. We will use the TAS: (l) to better understand the pharmacokinetics of transcutaneous ethanol across a range of individuals differing in race, gender and skin conditions and to pilot test the device in non-alcoholic drinkers, under conditions of known alcohol consumption in a home setting; (2) in field-trials with non-alcoholic drinkers under naturalistic drinking conditions; and 3) with alcoholics in outpatient treatment. We will evaluate utility and acceptance of the TAS device and compare its ability to assess alcohol consumption with traditional measures of assessment, such as self-report, collateral report and clinician assessment.