Information theoretic assays of exploration in aged mice
Information theoretic assays of exploration in aged mice
批准号:
7244069
负责人:
STEPHEN J BONASERA
金额:
$15.65万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-06-15 至 2009-04-30
关键词:
AddressAdoptionAdvanced DevelopmentAge-MonthsAgingAlgorithmsAlzheimer&aposs DiseaseAnimalsBehaviorBehavioralBiological AssayBrainCognitiveCognitive deficitsCommunitiesComplexDataDementiaElderlyEmotionalEntropyEnvironmentExploratory BehaviorFaceFemaleFutureGeneticGroomingHumanImpaired cognitionIndividualInformation TheoryKnowledgeLocationMeasuresMemoryMethodsMetricModelingMorbidity - disease rateMotor ActivityMovementMusNeurodegenerative DisordersNeurosciencesNeurotransmittersOdorsPatientsPatternPersonsPhenotypePrincipal Component AnalysisProcessPropertyRangeRateSerial LearningStatistical DistributionsStretchingSystemTechniquesValidationWeightWorkage relatedagedbasebehavior changebehavior measurementcognitive changecohortdisabilityinnovationinsightmalemanmiddle ageneurophysiologynormal agingnovelresponsetoolvector
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Normal aging is accompanied by alterations in both cognitive and emotional function. While these changes are of modest significance in otherwise healthy elders, they can have devastating impacts in persons with dementia or cognitive impairment. Unfortunately, current knowledge of the basic neuroscience underlying behavioral disturbances in the elderly remains very poorly understood. Aged mice are appropriate models to address this significant deficit. Neurophysiology of the aging mouse brain resembles that seen in man, and many behaviors observable in mice have close human parallels. For example, in both mouse and man there is an age-related decline in gross exploration of a new environment. Exploratory behavior is modulated in a specific manner by different neurotransmitter systems; thus, sophisticated analyses of exploratory behavior can provide important insights into age-related changes in CNS function. Currently, powerful tools to study exploratory behavior are lacking; we propose to develop these tools. We will develop a multiple behavioral state (MBS) representation of arena influences on mouse location, mouse locomotor activity (stop/pausing, turning, and progression), and other mouse ethological parameters (rearing, stretching, grooming, etc.). We will then extend this approach to study how acquisition of place memories alters variables within the MBS model. The entropy rate and predictive information will be calculated for these data and used to quantify the amount of randomness and complexity of the responses. Validation data will be collected in young (6 wk), mid-life (12 month) and aged (>24 month) C57BI6 mouse cohorts. Our preliminary results show that aged mice have less complex novel environment exploratory patterns compared to a younger cohort. The analytic tools developed in this study will be invaluable when evaluating the efficacy of future pharmacological or genetic-based therapies to enhance cognitive and emotional function in patients with dementia.
期刊论文(2)
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科研奖励(0)
会议论文
Modifying age-related changes in mouse neuroinflammation & functional behaviors
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批准号:7853928
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项目类别:
-
资助金额:$57.33万
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财政年份:2009
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负责人:STEPHEN J BONASERA
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依托单位:
Modifying age-related changes in mouse neuroinflammation & functional behaviors
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批准号:8278555
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项目类别:
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资助金额:$58.52万
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财政年份:2009
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负责人:STEPHEN J BONASERA
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依托单位:
Modifying age-related changes in mouse neuroinflammation & functional behaviors
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批准号:7812143
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项目类别:
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资助金额:$64.43万
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财政年份:2009
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负责人:STEPHEN J BONASERA
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依托单位:
Modifying age-related changes in mouse neuroinflammation & functional behaviors
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批准号:8457079
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项目类别:
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资助金额:$52.45万
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财政年份:2009
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负责人:STEPHEN J BONASERA
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依托单位:
Modifying age-related changes in mouse neuroinflammation & functional behaviors
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批准号:8061708
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项目类别:
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资助金额:$58.77万
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财政年份:2009
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负责人:STEPHEN J BONASERA
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依托单位:
Information theoretic assays of exploration in aged mice
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批准号:7048089
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项目类别:
-
资助金额:$18.04万
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财政年份:2006
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负责人:STEPHEN J BONASERA
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依托单位:
Serotonergic Regulation of Behavioral Disinhibition
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批准号:6617071
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项目类别:
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资助金额:$13.34万
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财政年份:2003
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负责人:STEPHEN J BONASERA
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依托单位:
Serotonergic Regulation of Behavioral Disinhibition
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批准号:7255727
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项目类别:
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资助金额:$13.44万
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财政年份:2003
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负责人:STEPHEN J BONASERA
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依托单位:
Serotonergic Regulation of Behavioral Disinhibition
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批准号:6771041
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项目类别:
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资助金额:$13.36万
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财政年份:2003
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负责人:STEPHEN J BONASERA
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依托单位:
Serotonergic Regulation of Behavioral Disinhibition
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批准号:7097386
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项目类别:
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资助金额:$13.4万
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财政年份:2003
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负责人:STEPHEN J BONASERA
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依托单位:
Serotonergic Regulation of Behavioral Disinhibition
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批准号:6923954
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项目类别:
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资助金额:$13.39万
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财政年份:2003
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负责人:STEPHEN J BONASERA
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依托单位:
海外基金