Harnessing lipid-reactive immunity to combat Mycobacterium tuberculosis infection

利用脂质反应免疫来对抗结核分枝杆菌感染

• 批准号: nhmrc : 1056277
• 负责人: Dr Lucia Mori
• 金额: $ 22.77万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/harnessing-lipid-reactive-tuberculosis-infection/112536
• 关键词: Harnessing; lipid; reactive; immunity; combat

Critcial to the survival of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB) is its unique waxy (lipid)-rich cell wall. This proposal aims to target components of its cell wall to devlop novel therapeutic strategies. Specifically, the Australian-Singapore alliance will examine how the immune system "sees" lipid based antigens from M. tuberculosis, and then will ultimately use this information towards the devlopment of novel lipid-based vaccines.

对结核分枝杆菌的生存至关重要，结核病（TB）的病原体是其独特的富含蜡（脂质）的细胞壁。该提案旨在靶向其细胞壁的组分，以开发新的治疗策略。具体来说，澳大利亚-新加坡联盟将研究免疫系统如何“看到”来自M。结核病，然后将最终使用这些信息对开发新的脂质为基础的疫苗。