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Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis

Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
针对帕塔纳托细胞焦亡的调节性坏死途径的辐射缓解剂
批准号：
10838232
负责人：
Hülya Bayir
金额：
$48.07万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-05-08 至 2025-06-30
来源：
https://reporter.nih.gov/project-details/10838232
关键词：
AccidentsAcuteAntibodiesAntigensApoptosisApoptoticBacteriaBloodCASP1 geneCell DeathCell Membrane PermeabilityCell NucleusCell membraneCessation of lifeChemotactic FactorsComputer ModelsDataDevelopmentDiseaseDoseEffectivenessEpithelial CellsEventExposure toFree RadicalsFundingGenerationsGoalsIL18 geneIn VitroInfectionInflammasomeInflammatoryInflammatory ResponseInterleukin-1 ReceptorsInterleukin-1 betaIntestinesIonizing radiationKnowledgeLinkLipidsMediatingMedicalMitochondriaMitochondrial ProteinsMolecularNecrosisNuclearNuclear TranslocationNuclear WarfareOuter Mitochondrial MembraneOxidation-ReductionParticipantPathogenesisPathogenicityPathway interactionsPhospholipidsPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) PolymerasesProductionProteinsRadiationRadiation InjuriesRadiation exposureRadioactiveRadiology SpecialtyReactive Oxygen SpeciesRecoveryRoleSignal PathwaySignal TransductionStreamStressStructure-Activity RelationshipSyndromeTestingTherapeuticTissuesWaterWhole-Body Irradiationanakinraapoptosis inducing factorbone marrow hyperplasiaclinical translationcytokinedesigneffectiveness evaluationgastrointestinal epitheliumimprovedin vivo Modelinhibitorinterestirradiationlipid biosynthesislipid mediatorlipidomicsnovelnovel therapeuticsoxidationpathogenprogramsradiation mitigationradiation mitigatorradiological attackresponsesmall molecule inhibitortrafficking

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