Dissecting the nitrogen regulation system of streptomycetes
剖析链霉菌的氮调节系统
基本信息
- 批准号:BB/D018226/1
- 负责人:
- 金额:$ 69.08万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2006
- 资助国家:英国
- 起止时间:2006 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Streptomycetes are harmless soil bacteria that are the primary source of the vast majority of antibiotics that we use to cure infectious disease, as well as providing us with numerous other medicines that are used, for example, to treat cancer and to help organ transplant patients. Most of these compounds are called secondary metabolites, in that their synthesis is dispensable and often occurs late in the growth cycle. Amongst the bacteria, streptomycetes are also relatively unusual in that they have a complex life cycle during which they undergo a number of changes in cell shape and form leading to the production of a chain of robust spores that are dispersed and then germinate to repeat the cycle. Both the production of antibiotics and the differentiation process occur only under certain conditions, one of which is a limitation on the availability of nitrogen sources. In many bacteria the complex control processes that allow the cell to determine whether it is short of nitrogen are well understood, but up until now we have not determined exactly how this process works in streptomycetes. We plan to use a combination of our knowledge of how this process of 'nitrogen control' works in other bacteria, together with recent information on all the genes that are present in streptomycetes, to begin to dissect the sensors and switches that make up the nitrogen control system in these economically important bacteria. If we can achieve this, it will provide important information that will allow us to manipulate these bacteria to control when they begin to synthesise important compounds such as antibiotics, and the amounts produced.
链霉菌是无害的土壤细菌,是我们用来治疗传染病的绝大多数抗生素的主要来源,也为我们提供了许多其他药物,例如,用于治疗癌症和帮助器官移植患者。这些化合物中的大多数被称为次生代谢物,因为它们的合成是不必要的,通常发生在生长周期的后期。在细菌中,链霉菌也相对不寻常,因为它们有一个复杂的生命周期,在此期间它们在细胞形状和形式上经历了许多变化,导致产生一系列健壮的孢子,这些孢子散布开来,然后萌发重复这个循环。抗生素的生产和分化过程都只在特定的条件下发生,其中之一是对氮源的可获得性的限制。在许多细菌中,允许细胞确定是否缺氮的复杂控制过程是众所周知的,但到目前为止,我们还没有确定这一过程在链霉菌中是如何工作的。我们计划结合我们对其他细菌如何进行“氮素控制”的知识,以及链霉菌中存在的所有基因的最新信息,开始剖析这些经济上重要的细菌中组成氮素控制系统的传感器和开关。如果我们能做到这一点,它将提供重要的信息,使我们能够操纵这些细菌,以控制它们何时开始合成抗生素等重要化合物,以及产生的数量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mike Merrick其他文献
Complementation analysis of glnA-linked mutations which affect nitrogen fixation in Klebsiella pneumoniae
- DOI:
10.1007/bf00272907 - 发表时间:
1981-12-01 - 期刊:
- 影响因子:2.100
- 作者:
Guadalupe Espin;Ariel Alvarez-Morales;Mike Merrick - 通讯作者:
Mike Merrick
Regulation of the nitrogen fixation genes inKlebsiella pneumoniae: Implications for genetic manipulation
肺炎克雷伯菌固氮基因的调控:对基因操作的影响
- DOI:
- 发表时间:
1986 - 期刊:
- 影响因子:4.9
- 作者:
Ray Dixon;Martin Buck;Martin Drummond;T. Hawkes;Haseena Khan;S. MacFarlane;Mike Merrick;John Postgate - 通讯作者:
John Postgate
TheKlebsiella pneumoniae PII protein (glnB gene product) is not absolutely required for nitrogen regulation and is not involved in NifL-mediatednif gene regulation
肺炎克雷伯菌 PII 蛋白(glnB 基因产物)并不是氮调节所必需的,并且不参与 NifL 介导的 nif 基因调节
- DOI:
10.1007/bf02464920 - 发表时间:
1989 - 期刊:
- 影响因子:0
- 作者:
A. Holtel;Mike Merrick - 通讯作者:
Mike Merrick
The product of the nitrogen fixation regulatory gene nfrX of Azotobacter vinelandii is functionally and structurally homologous to the uridylyltransferase encoded by glnD in enteric bacteria
维氏固氮菌固氮调节基因 nfrX 的产物与肠道细菌中 glnD 编码的尿苷酰转移酶在功能和结构上同源
- DOI:
- 发表时间:
1991 - 期刊:
- 影响因子:3.2
- 作者:
Asunción Contreras;M. Drummond;A. Bali;G. Blanco;E. García;G. Bush;C. Kennedy;Mike Merrick - 通讯作者:
Mike Merrick
Analysis of the Klebsiella pneumoniae ntrB gene by site‐directed in vitro mutagenesis
通过定点体外诱变分析肺炎克雷伯菌ntrB基因
- DOI:
- 发表时间:
1987 - 期刊:
- 影响因子:3.6
- 作者:
S. A. MacFarlane;Mike Merrick - 通讯作者:
Mike Merrick
Mike Merrick的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mike Merrick', 18)}}的其他基金
Systems Approach to Biological Research Studentship
生物研究学生资助的系统方法
- 批准号:
BB/H531778/1 - 财政年份:2010
- 资助金额:
$ 69.08万 - 项目类别:
Training Grant
The role of protein complexes and protein localisation in regulation of bacterial nitrogen metabolism
蛋白质复合物和蛋白质定位在调节细菌氮代谢中的作用
- 批准号:
BB/E022308/1 - 财政年份:2007
- 资助金额:
$ 69.08万 - 项目类别:
Research Grant
相似海外基金
Exploring the Role of Nitrogen Metabolism in Cancer
探索氮代谢在癌症中的作用
- 批准号:
10737792 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
Active-site models unravel mechanism of enzymatic alkane activation
活性位点模型揭示了酶促烷烃活化的机制
- 批准号:
10711929 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
The role and mechanism of RNA m6A modification in the pathogenesis and drug-resistance of prostate cancer
RNA m6A修饰在前列腺癌发病及耐药中的作用及机制
- 批准号:
10638634 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
Metabolic determinants of Staphylococcus aureus skin colonization
金黄色葡萄球菌皮肤定植的代谢决定因素
- 批准号:
10749745 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
The role of tyrosine metabolism in tuberculosis pathogenesis
酪氨酸代谢在结核病发病机制中的作用
- 批准号:
10639965 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
A systems biology approach to elucidating mechanisms underlying amino acid toxicities
阐明氨基酸毒性机制的系统生物学方法
- 批准号:
10680272 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
Modulation of Macrophage Antifungal Activity by the Transcriptional Co-regulator CITED1
转录辅助调节因子 CITED1 对巨噬细胞抗真菌活性的调节
- 批准号:
10727860 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
Defining the role of phosphatidic acid as an allosteric regulator of mitochondrial glutaminase
定义磷脂酸作为线粒体谷氨酰胺酶变构调节剂的作用
- 批准号:
10639525 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
RNA-binding proteins in bacterial virulence and host-pathogen interactions
RNA结合蛋白在细菌毒力和宿主-病原体相互作用中的作用
- 批准号:
10659346 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别:
A tRNA synthetase is an amino acid sensor for TOR in plants
tRNA 合成酶是植物中 TOR 的氨基酸传感器
- 批准号:
10795209 - 财政年份:2023
- 资助金额:
$ 69.08万 - 项目类别: