STRUCTURE-FUNCTION STUDIES OF CYSTEINE PROTEASES OF PARASITIC DISEASE AND ALLERG

寄生虫病和过敏症半胱氨酸蛋白酶的结构功能研究

• 批准号: 7370456
• 负责人: LINDA S BRINEN
• 金额: $ 0.09万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7370456
• 关键词: STRUCTURE; FUNCTION; STUDIES; CYSTEINE; PROTEASES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cysteine proteases are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological processes and diseases, including antigen processing, bacterial infection, arthritis, osteoporosis, Alzheimer¿¿s disease and cancer cell invasion. Several cysteine proteases of the papain superfamily are critical to the life-cycle progression of many pathogenic protozoa and therefore they represent potential targets for selective inhibitor design. It has also been determined that members of this same class of enzyme are required for human allergic and asthmatic response to the common house dust mite. High-resolution structural studies have provided valuable information for the design of anti-parasitic therapeutics that selectively regulate the cysteine protease cruzain, a key enzyme in the lifecycle of T. cruzi, the causative agent of Chagas¿¿ disease. The studies detailed in this program will expand our understanding and ability to regulate several new protease targets indicated in a variety of parasitic infections as well as proteases of dust mite allergy induced asthma.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。半胱氨酸蛋白酶存在于几乎所有真核生物群中，并在广泛的生物过程和疾病中发挥重要作用，包括抗原加工、细菌感染、关节炎、骨质疏松症、阿尔茨海默病和癌细胞侵袭。木瓜蛋白酶超家族的几种半胱氨酸蛋白酶对许多病原性原生动物的生命周期进展至关重要，因此它们代表了选择性抑制剂设计的潜在靶标。还已经确定，人类对常见的屋尘螨的过敏和哮喘反应需要这同一类酶的成员。高分辨率的结构研究为设计抗寄生虫药物提供了有价值的信息，这些药物选择性地调节半胱氨酸蛋白酶cruzain，这是T. cruzi，南美锥虫病的病原体。该计划中详细的研究将扩大我们的理解和能力，以调节各种寄生虫感染中指示的几种新的蛋白酶靶标以及尘螨过敏诱导的哮喘的蛋白酶。