STRUCTURAL STUDIES OF LUNG SURFACTANT PROTEIN

肺表面活性蛋白的结构研究

• 批准号: 6586743
• 负责人: LINDA S BRINEN
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586743
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; respiratory system; structural biology

Lung surfactant protein A is an important structural component of mammalian lungs. The carboxy terminal domain of this protein recognizes and binds carbohydrate at neutral pH and in the presence of Ca2+. This domain also shows significant sequence similarity to the carbohydrate recognition domains of other animal lectins which require neutral pH and Ca2+ to bind carbohydrate. The precise function and mechanisms of the carbohydrate recognition domain (CRD) of lung surfactant protein A are unknown, however, evidence that this protein plays a role in establishing and maintaining the architectural integrity of the lung as well as in clearing the lung of invading pathogens does exist. The goal of this project is to define a molecular-level structural basis for these observed functions via the X-ray crystallographic structure determination of the CRD of human, rat, and mouse lung surfactant protein A.

肺表面活性剂蛋白A是肺的重要结构成分