STRUCTURE-FUNCTION STUDIES OF CYSTEINE PROTEASES OF PARASITIC DISEASE AND ALLERG

寄生虫病和过敏症半胱氨酸蛋白酶的结构功能研究

• 批准号: 8362051
• 负责人: LINDA S BRINEN
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362051
• 关键词: Allergic; Alzheimer' s Disease; Arthritis; Asthma; Bacterial Infections; Biological Process; Cysteine Protease; Disease; Enzymes; Eukaryota; Funding; Grant; Human; Hypersensitivity; Life Cycle Stages; National Center for Research Resources; Osteoporosis; Papain; Parasitic Diseases; Parasitic infection; Peptide Hydrolases; Play; Principal Investigator; Protozoa; Pyroglyphidae; Radiation; Research; Research Infrastructure; Resolution; Resources; Role; Source; Structure; Therapeutic; Trypanosoma cruzi; United States National Institutes of Health; antigen processing; cancer cell; cost; cruzain; design; inhibitor/antagonist; member; programs; pyroglyphid; response; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cysteine proteases are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological processes and diseases, including antigen processing, bacterial infection, arthritis, osteoporosis, Alzheimer?s disease and cancer cell invasion. Several cysteine proteases of the papain superfamily are critical to the life-cycle progression of many pathogenic protozoa and therefore they represent potential targets for selective inhibitor design. It has also been determined that members of this same class of enzyme are required for human allergic and asthmatic response to the common house dust mite. High-resolution structural studies have provided valuable information for the design of anti-parasitic therapeutics that selectively regulate the cysteine protease cruzain, a key enzyme in the lifecycle of T. cruzi, the causative agent of Chagas? disease. The studies detailed in this program will expand our understanding and ability to regulate several new protease targets indicated in a variety of parasitic infections as well as proteases of dust mite allergy induced asthma.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 半胱氨酸蛋白酶存在于几乎所有的真核生物群中，并在广泛的生物过程和疾病中发挥重要作用，包括抗原加工，细菌感染，关节炎，骨质疏松症，阿尔茨海默病？的疾病和癌细胞的侵袭。木瓜蛋白酶超家族的几种半胱氨酸蛋白酶对许多病原性原生动物的生命周期进展至关重要，因此它们代表了选择性抑制剂设计的潜在靶标。还已经确定，人类对常见的屋尘螨的过敏和哮喘反应需要这同一类酶的成员。高分辨率的结构研究为设计抗寄生虫药物提供了有价值的信息，这些药物选择性地调节半胱氨酸蛋白酶cruzain，这是T. cruzi，南美锥虫病的病原体？疾病该计划中详细的研究将扩大我们的理解和能力，以调节各种寄生虫感染中指示的几种新的蛋白酶靶标以及尘螨过敏诱导的哮喘的蛋白酶。