IMPROVING METABOLIC ASSESSMENTS IN TYPE 1 DIABETES MELLITUS CLINICAL TRIALS

改进 1 型糖尿病临床试验中的代谢评估

• 批准号: 7368253
• 负责人: FRANCINE R. KAUFMAN
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368253
• 关键词: IMPROVING; METABOLIC; ASSESSMENTS; TYPE; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective is to compare the reliability of measures of stimulated C-peptide response derived from the 2-hour MMTT and the glucagon stimulation test (GST), including time to peak C-peptide on MMTT, and the peak and AUC values from each test. The primary outcome is the coefficient of reproducibility or the intraclass correlation of the MMTT provided from the duplicate tests within the participants with repeat MMTT, and the coefficient of reproducibility of the glucagon infusion test from the duplicate tests. All participants will be asked to do four tests, 2 MMTT's and 2 GST's.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。主要目的是比较两种方法测量刺激C肽反应的可靠性，包括MMTT法测定C肽峰值的时间、两种试验的峰值和AUC值。主要结果是重复试验提供的MMTT值的重复性系数或组内相关性，以及重复试验提供的胰升糖素输注试验的重复性系数。所有参与者将被要求进行四项测试，两项MMTT测试和两项GST测试。