IMPROVING METABOLIC ASSESSMENTS IN TYPE 1 DIABETES MELLITUS CLINICAL TRIALS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective is to compare the reliability of measures of stimulated C-peptide response derived from the 2-hour MMTT and the glucagon stimulation test (GST), including time to peak C-peptide on MMTT, and the peak and AUC values from each test. The primary outcome is the coefficient of reproducibility or the intraclass correlation of the MMTT provided from the duplicate tests within the participants with repeat MMTT, and the coefficient of reproducibility of the glucagon infusion test from the duplicate tests. All participants will be asked to do four tests, 2 MMTT's and 2 GST's.