THE TRIALNET NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 TrialNet自然史研究的目的是获得有关1型糖尿病（T1 D）发病机制和自然史的信息，并促进招募和评估可能有资格参加T1 D预防试验的个人。 TrialNet自然史研究旨在阐明在T1 D发展中起关键作用的遗传和免疫因素，以及早期代谢异常的特征日益增加。在此过程中，TrialNet自然史研究将有助于TrialNet T1 D预防试验的开发和实施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Purpose of TrialNet Natural History Study is to gain information about the pathogenesis and natural history of Diabetes Type 1 (T1D) and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials. The TrialNet Natural History Study has been designed to clarify the genetic and immunologic factors that play a key role in the development of T1D, and the increasing characterization of the early metabolic abnormalities. In doing so, TrialNet Natural History Study will contribute to the development and implementation of TrialNet T1D prevention trials.