Bioprocessing of genetically engineered filamentous phages to underpin new therapeutic and industrial applications

基因工程丝状噬菌体的生物加工支持新的治疗和工业应用

基本信息

  • 批准号:
    BB/D521465/1
  • 负责人:
  • 金额:
    $ 30.94万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

The extensive knowledge of phage (also known as bacteriophages and bacterial viruses) genetics and physiology acquired in the past 50 years makes them an attractive option for development of products for pharmaceutical, diagnostic and nanotechnological applications. Modified phages are showing promise in the battle to defeat infectious and genetic diseases. For example, it has been shown that HIV epitopes displayed on a filamentous phage can elicit T-cell and B-cell responses offering a novel approach for vaccine design for a disease that affects approximately 6 million world-wide. Modified phages can be synthesised in high titres in E. coli and in principle processed by techniques readily applicable to considerable scale-up. Until a recently resurgence of interest in phages as anti-microbial agents there has been little research concern with large-scale processing since a few early studies 30 years ago. For this reason modern biochemical engineering and molecular biology concepts have yet to be brought together to address the issues involved. The proposed study will examine these. As the crisis in antibiotic drug resistance by microorganisms continues to develop it is also possible that phages will have an antibiotic role. Though this is not the primary focus of this research, the biochemical engineering studies proposed will bear on to this related field.
过去 50 年中获得的噬菌体(也称为噬菌体和细菌病毒)遗传学和生理学的广泛知识使其成为制药、诊断和纳米技术应用产品开发的有吸引力的选择。修饰噬菌体在战胜传染病和遗传性疾病的战斗中显示出了希望。例如,研究表明,丝状噬菌体上展示的 HIV 表位可以引发 T 细胞和 B 细胞反应,为针对影响全球约 600 万人的疾病的疫苗设计提供了一种新方法。修饰的噬菌体可以在大肠杆菌中以高滴度合成,并且原则上通过易于适用于相当大的放大的技术进行加工。直到最近人们对噬菌体作为抗微生物剂的兴趣重新兴起,自 30 年前的一些早期研究以来,很少有研究关注大规模加工。因此,现代生化工程和分子生物学概念尚未结合起来解决所涉及的问题。拟议的研究将检验这些。随着微生物对抗生素耐药性的危机不断发展,噬菌体也有可能发挥抗生素作用。虽然这不是本研究的主要焦点,但所提出的生化工程研究将涉及到这一相关领域。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Determination of the survival of bacteriophage M13 from chemical and physical challenges to assist in its sustainable bioprocessing
  • DOI:
    10.1007/s12257-012-0776-9
  • 发表时间:
    2013-06-01
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Branston, Steven D.;Stanley, Emma C.;Keshavarz-Moore, Eli
  • 通讯作者:
    Keshavarz-Moore, Eli
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John Ward其他文献

Factors associated with delayed treatment onset for acute myocardial infarction in Victorian emergency departments: a regression tree analysis.
与维多利亚州急诊室急性心肌梗死延迟治疗相关的因素:回归树分析。
Respiratory Failure in Acute Infective Endocarditis, Trends and Outcomes: Data From the National Inpatient Sample From 1999-2014
  • DOI:
    10.1016/j.chest.2017.08.093
  • 发表时间:
    2017-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Adnan Khalif;Prateeth Pati;Balaji Shanmugam;Stuthi Perimbeti;John Ward
  • 通讯作者:
    John Ward
Accelerating biocatalytic process design: Integrating new tools from biology, chemistry and engineering
  • DOI:
    10.1016/j.jbiotec.2007.07.136
  • 发表时间:
    2007-09-01
  • 期刊:
  • 影响因子:
  • 作者:
    Frank Baganz;Bing Chen;Paul Dalby;Ed Hibbert;Gary Lye;Martina Micheletti;John Woodley;Ursula Kaulmann;John Ward;Helen Hailes;Mark Smith;Kirstie Smithies
  • 通讯作者:
    Kirstie Smithies
FRI-174 - Challenges and strategies to improve linkage to care and treatment for hepatitis C in pregnancy: perspectives from a global community of practice
  • DOI:
    10.1016/s0168-8278(23)02937-9
  • 发表时间:
    2023-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Neil Gupta;Lindsey Hiebert;Martina Badell;Megan Buresh;Catherine Chappell;Manal Hamdy El-Sayed;Saeed Sadiq Hamid;Ravi Jhaveri;Ali Judd;Tatyana Kushner;Mona Prasad;Jennifer Price;John Ward
  • 通讯作者:
    John Ward
Evolving Research on Groundwater Governance and Collective Action for Water Security: A Global Bibliometric Analysis
地下水治理和水安全集体行动研究的发展:全球文献计量分析
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    5.9
  • 作者:
    Susmina Gajurel;Basant Maheshwari;D. Hagare;John Ward;Pradeep Singh
  • 通讯作者:
    Pradeep Singh

John Ward的其他文献

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{{ truncateString('John Ward', 18)}}的其他基金

17-ERACoBioTech Enzyme platform for the synthesis of chiral aminoalcohols
17-ERACoBioTech 用于合成手性氨基醇的酶平台
  • 批准号:
    BB/R021627/1
  • 财政年份:
    2018
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
Refining Oxidative Enzyme Systems from Talented Microorganisms for Industrial Biocatalysis.
从用于工业生物催化的天才微生物中精炼氧化酶系统。
  • 批准号:
    BB/N010523/1
  • 财政年份:
    2016
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
14TSB_SynBio A toolchest for rapid bootstrapping of novel chassis organisms
14TSB_SynBio 用于快速引导新型底盘生物的工具箱
  • 批准号:
    BB/M005607/1
  • 财政年份:
    2014
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
Metagenomics for new tools in synthetic biology to produce high value chemicals and products
用于合成生物学新工具的宏基因组学,用于生产高价值化学品和产品
  • 批准号:
    BB/L010801/1
  • 财政年份:
    2014
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
Metagenomics for new enzyme discovery and industrial biocatalysis
用于新酶发现和工业生物催化的宏基因组学
  • 批准号:
    BB/L007444/1
  • 财政年份:
    2014
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
MRes in Synt0etic Biology
合成生物学硕士
  • 批准号:
    BB/H021027/1
  • 财政年份:
    2010
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Training Grant
Synthetic Biology Pathways to Isoquinoline Alkaloids
异喹啉生物碱的合成生物学途径
  • 批准号:
    BB/G014426/1
  • 财政年份:
    2009
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
Creating a user friendly Transaminase toolkit
创建用户友好的转氨酶工具包
  • 批准号:
    EP/G005834/1
  • 财政年份:
    2009
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
UK Mathematics-in-medicine study group: Loughborough University 2008
英国医学数学研究小组:拉夫堡大学 2008
  • 批准号:
    EP/G020450/1
  • 财政年份:
    2008
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant
'Synbion' The UCL Network in Synthetic Biology
“Synbion”伦敦大学学院合成生物学网络
  • 批准号:
    BB/F018703/1
  • 财政年份:
    2008
  • 资助金额:
    $ 30.94万
  • 项目类别:
    Research Grant

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Expression regulation and morphological and function analysis of Piezo1 and Piezo2 in the kidney using genetically engineered mice
基因工程小鼠肾脏中 Piezo1 和 Piezo2 的表达调控及形态和功能分析
  • 批准号:
    23K07704
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使用基因工程人类 iPSC 进行精神分裂症罕见变异的功能表征
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PLA2G2D Antibodies for Cancer Immunotherapy
用于癌症免疫治疗的 PLA2G2D 抗体
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UBR5在肿瘤发生和免疫调节中的作用机制
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胰腺癌研究项目
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醋酸盐和内皮病理学
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    10736268
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