Epigenetic regulation of nutrient sensing in the prostate

前列腺营养感应的表观遗传调控

• 批准号: BB/D523651/1
• 负责人: Christopher McCabe
• 金额: $ 36.42万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD523651%2F1
• 关键词: Epigenetic; regulation; nutrient; sensing; prostate

It is clear that a broad diet, with plenty of fresh fruit and vegetables is required for growth as a child and health as an adult. Surprisingly little is really understood of how many of these food substances help the body to stay healthy. A family of proteins in human cells, called nuclear receptors, bind to small substances, which are part of a healthy diet, such as vitamins. Each receptor acts like a lock, and binds to a specific substance or group of closely related ones, like a key. These receptors are attached to specific genes inside cells, and when the correct key is in the lock it is able to unfold a gene and allow it to be turned on. The gene then makes a protein which controls how the cell grows and dies. This unfolding is known as epigenetics and is very tightly controlled because not every cell needs every gene to function correctly. This is important because it has become clear that even in adults the body still grows. To keep size constant the body controls the rate at which cells grow, divide and die, with those that die being replaced by new ones. This depends on the correct genes being unfolded at the right time and others being kept locked away. Sometimes in old age or during cancer these controls are lost and lead to problems. In men for example this can affect how the size of one gland, the prostate, is controlled. The understanding that food signals can bind to specific receptors and control the function of cells is important and this grant will analyse the direct mechanisms by which these nutrient signals are sensed, often balanced with other signals, and act to unfold specific gene targets. This will help other scientists to understand what is important in a healthy diet and help people of all ages to be more healthy and live longer.

很明显，广泛的饮食，包括大量的新鲜水果和蔬菜，是儿童成长和成人健康所必需的。令人惊讶的是，人们对这些食物中有多少能帮助身体保持健康知之甚少。人类细胞中有一种叫做核受体的蛋白质家族，它与维生素等健康饮食中的小物质结合。每个受体的作用就像一把锁，与一种特定的物质或一组密切相关的物质结合，就像一把钥匙。这些受体附着在细胞内的特定基因上，当正确的钥匙在锁上时，它就能打开一个基因，并允许它被打开。然后，该基因产生一种蛋白质，控制细胞的生长和死亡。这种展开被称为表观遗传学，它受到非常严格的控制，因为不是每个细胞都需要每个基因才能正常工作。这一点很重要，因为很明显，即使是成年人，身体仍在生长。为了保持大小不变，身体控制细胞生长、分裂和死亡的速度，死亡的细胞被新的细胞所取代。这取决于正确的基因在正确的时间展开，而其他基因则被锁起来。有时在老年或癌症期间，这些控制失去并导致问题。例如，在男性中，这可能会影响一个腺体的大小，即前列腺的控制。了解食物信号可以与特定受体结合并控制细胞功能是很重要的，这项资助将分析这些营养信号被感知的直接机制，通常与其他信号平衡，并发挥作用以揭示特定的基因目标。这将帮助其他科学家了解健康饮食的重要性，并帮助所有年龄段的人更健康、更长寿。

项目成果

Nuclear receptors and the Warburg effect in cancer.

• DOI: 10.1002/ijc.29012
• 发表时间: 2015-10-01
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Thorne JL;Campbell MJ
• 通讯作者: Campbell MJ

Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.

• DOI: 10.1093/nar/gkq875
• 发表时间: 2011-03
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Thorne JL;Maguire O;Doig CL;Battaglia S;Fehr L;Sucheston LE;Heinaniemi M;O'Neill LP;McCabe CJ;Turner BM;Carlberg C;Campbell MJ
• 通讯作者: Campbell MJ

Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.

对前列腺癌细胞中VDR转录调控的表观遗传扭曲。

• DOI: 10.1016/j.jsbmb.2012.10.002
• 发表时间: 2013-07
• 期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 4.1
• 作者: Singh, Prashant K.;Doig, Craig L.;Dhiman, Vineet K.;Turner, Bryan M.;Smiraglia, Dominic J.;Campbell, Moray J.
• 通讯作者: Campbell, Moray J.