THE STRUCTURE AND FUNCTION OF HUMAN PHAGOCYTE FLAVOCYTOCHROME B

人吞噬细胞黄细胞色素B的结构和功能

• 批准号: 7369618
• 负责人: ALGIRDAS JOSEPH JESAITIS
• 金额: $ 1.26万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369618
• 关键词: STRUCTURE; FUNCTION; HUMAN; PHAGOCYTE; FLAVOCYTOCHROME

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flavocytochrome b is the central electron transferase of the NADPH oxidase of neutrophils, eosinophils, and monocytes/macrophages. This phagosomal and plasma membrane enzyme system is responsible for generating superoxide for host defense. Individuals deficient in this enzyme complex suffer severe life threatening infections with a disease called chronic granulomatous disease. Unregulated superoxide production is also pathogenic in a wide variety of inflammatory diseases. The flavocytochrome has also now been recognized to a prototype for NADPH oxidases widely expressed in plants and animals serving in oxidative signaling and organismic defense. The 3D structure of flavocytochrome b, an integral membrane heterodimeric glycoprotein, remains unknown.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。黄细胞色素b是中性粒细胞、嗜酸性粒细胞和单核/巨噬细胞NADPH氧化酶的中心电子转移酶。这种吞噬小体和质膜酶系统负责产生用于宿主防御的超氧化物。缺乏这种酶复合体的人会患上一种名为慢性肉芽肿病的严重威胁生命的感染。不受控制的超氧化物的产生也是多种炎症性疾病的致病因素。黄色素现在也被认为是NADPH氧化酶的原型，在植物和动物中广泛表达，参与氧化信号和有机体防御。黄细胞色素b是一种完整的膜异二聚体糖蛋白，其三维结构尚不清楚。